Endocrine Abstracts

Introduction: Salivary cortisol measurement, representing free cortisol, seems to be a promissing alternative method to serum cortisol. Besides its use in the diagnostics of hypercortisolism, it could be of help in evaluation of adrenocortical reserve. It might be useful especially in patients on estrogen replacement, which modulates transcortin and hence total cortisol levels.Aims: Compare the reliability of salivary vs. serum cortisol assessment during...

Introduction: Hypothalamo-pituitary dysfunction has been reported in patients after traumatic brain injury or subarachnoid hemorrhage with relatively high frequency according to published studies. Assessment of hypothalamo– pituitary functions in patients with chronic subdural hematomas has not been published yet, although dysfunction of hypothalamo- pituitary unit could be expected (head trauma, compression and oedema of the brain, shifting of the midline structures).</p...

Certain degree of hypopituitarism has been revealed in a significant number of patients who suffered traumatic brain injuries or subarachnoid hemorrhage. Microhemorrhages, necrosis, tissue infarcts and vasoconstriction are reported as mechanism of hypothalamo-pituitary dysfunction. Assessment of hypothalamo-pituitary endocrine functions in patients with chronic subdural hematomas has not been published yet, although dysfunction of hypothalamo-pituitary unit can be expected (he...

Introduction: Although some studies have shown elevated soluble interleukin 2 receptor (sIL-2R) in sera of patients with hematological malignancies and some autoimmune diseases, its role in serum is not fully understood.Patients and methods: The aim was to compare serum levels of sIL-2R in four groups of women (11 with Graves’ disease, 10 with Hashimoto’s thyroiditis, 11 with breast cancer and 10 healthy controls) and to test their possible rel...

Objective: Fibroblast growth factor 19 (FGF-19) and FGF-21 are novel metabolic regulators that improve insulin resistence and obesity in rodents. The objective of this study was to explore whether changes in serum concentrations of FGF-19 and FGF-21 contribute to positive metabolic effects of weight loss induced by surgical treatment of obesity – sleeve gastrectomy (SG).Methods: Serum concentrations of FGF-19 and 21, adiponectin, resistin, fatty aci...