Searchable abstracts of presentations at key conferences in endocrinology

ea0011p248 | Cytokines and growth factors | ECE2006

Proinflammatory cytokine gene expression shows intrinsic circadian oscillation in peripheral cells

McMaster A , Lebiecki J , Loudon A , Donn R , Ray DW

An extraordinary array of behavioural and physiological systems is regulated by endogenous circadian timekeepers within mammals. This circadian machinery is comprised of intricate autoregulatory transcription feedback loops, which interact to generate a time delay of approximately 24 hours in the cyclical transcription of components. In addition to the master clock in the suprachiasmatic nucleus it is clear that peripheral tissues also express clock components. The central clo...