Searchable abstracts of presentations at key conferences in endocrinology

ea0003p54 | Clinical Case Reports | BES2002

Apparent mineralocorticoid excess caused by Barnips cough tablets

Lewandowski K , Burr W

Presentation: A 66 year old woman, was admitted as an emergency with one week history of profound weakness ('had to crawl to the fridge to get milk for tea'), lethargy, productive cough and hypokalaemia (GP results: Na 141, K 1.5, bicarbonate 47 (23-28), Creatinine 54 (μmol/l). Her medication: Amlodipine 5 mg od, Bendrofluazide 2.5 mg od, Aspirin 75 mg.PMH: hypertension, moderate COPD and peripheral vascular disease. She smoked 20 cigarettes a day an...

ea0019p121 | Diabetes, Metabolism and Cardiovascular | SFEBES2009

Concentrations of matrix metalloproteinase 2 and 9 in patients with type 2 diabetes and in non-diabetic controls

Lewandowski KC , Banach E , Lewinski A

Background: Matrix metalloproteinases (MMPs) remodel extracellular matrix (ECM) in physiology as well as in cancer, inflammatory states and cardiovascular disease. In type 2 diabetes, there is evidence of activation of MMPs in vasculature, while decreased activity of MMPs and excessive accumulation of ECM is thought to contribute to the development of diabetic nephropathy.Material and methods: We measured serum MMP-2, MMP-9 in 22 subjects with type 2 DM ...

ea0011p223 | Cytokines and growth factors | ECE2006

Low dose dexamethasone does not alter serum adiponectin or resistin concentrations

Lewandowski KC , Szosland K , Lewinski A

Background: Adiponectin and resistin belong to the group of adipocytokines, that are thought to be involved in regulation of insulin sensitivity, and that also exert the opposite effects on inflammatory processes related to atherosclerosis and cardiovascular risk. Glucocorticoids have anti-inflammatory properties, but also increase insulin resistance. There are, however, conflicting data on the effects of glucocorticoids on serum concentrations of adiponectin and resistin....

ea0037ep430 | Diabetes (complications & therapy) | ECE2015

COMMODITY12 telemedicine system is effective in primary care setting in patients with type 2 diabetes

Lewandowski Krzysztof , Mazurkiewicz Maciej , Kardas Przemyslaw

Background: The COMMODITY12 is a telemedicine system designed for continuous monitoring of diabetes type 1 (DM1) and DM2, as well as the cardiovascular comorbidities. The system has been created in collaboration of nine European academic and industrial partners under FP7 (www.commodity12.eu).Aim: The aim of this study was to assess clinical utility of the COMMODITY12 system in DM2 patients, under a design of a mini...

ea0035p363 | Diabetes (epidemiology, pathophysiology) | ECE2014

Intensive and expensive new treatments or better education for patients with diabetes: Where should we begin with?

Lewandowski Krzysztof , Basinska-Lewandowska Magdalena , Kardas Przemyslaw

Design and methods: Though several new treatments for diabetes (DM) are available, their effectiveness, however, might be limited, by patients knowledge. In order to test patients’ knowledge and self-management of diabetes, we had employed a questionnaire for clinic patients with types 1 and 2 DM. This was a pilot study for a telemetric medicine EU project (www.COMMODITY12.eu). Study involved 37 subjects (19 males) with type 1 (n=18) or insulin treated type 2 DM ...

ea0031p383 | Thyroid | SFEBES2013

Case report: when measured free T4 and free T3 may be misleading. Interference with free thyroid hormones measurements on Roche and Siemens platforms

Lewandowski Krzysztof , Dabrowska Katarzyna , Lewinski Andrzej

A 59-year-old female presented with apathy and 6 kg weight gain. Investigations revealed primary hypothyroidism (TSH >100 μIU/ml). Thyroxine (L-T4) was started and titrated up to 75 μg, o.d., with clinical improvement. Other investigations revealed high titres of anti-thyroid peroxidase and anti-thyroglobulin antibodies. After three months, there was a fall in TSH to 12.74 μIU/ml, however, with unexpectedly high free T4 (...

ea0029p1433 | Pituitary Clinical | ICEECE2012

Coexistence of macroprolactinaemia and hyperprolactinaemia in women with oligo-/amenorrhoea is associated with high risk of pituitary adenomas

Gasior-Perczak D. , Lewandowski K. , Kowalska A. , Lewinski A.

Background: The so called ‘big-big’ prolactin, also known as macroprolactin is formed by prolactin-immunoglobulin complexes, is considered to be biologically inactive, but may cause elevation of serum prolactin (Prl) concentrations measured by standard assays. In women presenting with oligo- and/or amenorrhoea the cause of menstrual irregularity needs to be explained even in the setting of concomitant macroprolactinaemia. We have therefore attempted to assess the pre...

ea0029p1741 | Thyroid (non-cancer) | ICEECE2012

Increase of Serum Adiponectin And Stable Concentrations of Matrix Metalloproteinases Confirm Safety of Radioiodine Treatment of Thyrotoxicosis

Lewinski A. , Brona A. , Lewandowski K. , Bienkiewicz M. , Milewicz A.

Background: Matrix metalloproteinases (MMPs), together with their tissue inhibitors (TIMPs), remodel extracellular matrix under physiological and pathological conditions and are implicated in pathogenesis of cardiovascular diseases, cancer and in chronic inflammation. We have endeavoured to assess whether concentrations of MMPs, TIMPs, proinflammtory thrombospondin and anti-inflammatory adiponectin are altered by administration of radioiodine during treatment of thyrotoxicosis...

ea0011p219 | Cytokines and growth factors | ECE2006

Adiponectin and resistin concentrations during oral glucose tolerance test (OGTT) in insulin-resistant subjects

Szosland K , Lewandowski K , Randeva H , Lewinski A

Background and aims: Mechanism underlying the IR (Insulin-resistance) remains yet to be identified. Resistin has been shown to antagonize insulin action, and thus might be implicated in the pathogenesis of IR. In contrast, adiponectin has been shown to increase insulin sensitivity and improve glucose tolerance. We aimed to test the hypothesis that resistin levels might correlate positively with the indices of insulin resistance, while the opposite might be true for adiponectin...

ea0009p221 | Clinical | BES2005

Adrenal crisis in an individual with panhypopituitarism and new-onset Graves' disease

Lewandowski K , Marcinkowska M , Makarewicz J , Lewinski A

Acute presentation: 46 year old patient was admitted as an emergency with vomiting, hypotension and serum cortisol of 26 nmol/L indicative of adrenal failure. Despite previous history of panhypopituitarism he was found to be hyperthyroid (free T4 6.32 ng/dL (0.93-1.7), free T3 22.21 pg/mL (1.8-4.6)).Past Medical History: He was fit & well till the age of 45. Eight months prior to this hospitalisation he presented with diabetes insipidus and was found...