Searchable abstracts of presentations at key conferences in endocrinology

ea0034s7.1 | Natriuretic peptides: so much more than salt and water | SFEBES2014

Guanylyl cyclases in cardiomyopathy

Kuhn Michaela

Natriuretic peptides and their cGMP-synthesizing guanylyl cyclase receptors (GC-A, receptor for ANP and BNP; GC-B, for CNP) are critically involved in the regulation of arterial blood pressure (all NPs) and skeletal growth (only CNP). Both receptors are expressed in all cardiac cell types, although at different densities. GC-A is expressed at higher levels in endothelial and smooth muscle cells, whereas GC-B predominates in myocytes and fibroblasts. In heart failure (HF) patie...

ea0026s9.2 | New endocrine aspects of diabetes mellitus | ECE2011

GLP-1 and the cardiovascular system

Diamant Michaela

The gut hormone glucagon-like peptide (GLP)-1 lowers blood glucose by stimulating meal-related insulin secretion and lowering hyperglucagonaemia in a glucose-dependent manner. Currently, injectable GLP-1 receptor agonists (GLP-1RA) and oral inhibitors of the dipeptidyl peptidase (DPP)-4 enzyme, that degrades native GLP-1, are successfully employed in the treatment of type 2 diabetes (T2DM). Clinically relevant extrapancreatic effects of GLP-1 (RA) involve slowing down gastric ...

ea0016me8 | (1) | ECE2008

microRNA

Scherr Michaela , Eder Matthias

MicroRNAs (miRNA) are small (18–24 nts) non-coding RNAs which are part of an evolutionarily highly conserved intracellular mechanism to regulate gene expression in a sequence-specific manner. These regulatory RNAs function by acting as sequence-specific guides which recruit multi-protein complexes to target mRNA sequences which are subsequently silenced. miRNAs are processed from primary transcripts (pri-miRNA) by cellular components which are also at least partially invo...

ea0016p626 | Reproduction | ECE2008

Influence of the 5 α-reductase inhibitor type 2 on circulating neuroactive steroids

Duskova Michaela , Hill Martin , Hanus Miroslav , Matouskova Michaela , Starka Luboslav

The 5α-reductase is one of the enzyme of steroid synthesis and founded in two isoformes. Two distinct 5α-reductase isoenzymes, type I and type II, are found across mammalian species. Each of these isoenzymes is differentially expressed in tissues and during distinct developmental stages and also in different species. The 5α-reductase is enzyme responsible for the reduction of testosterone to dihydrostestosterone, progesterone to dihydroprogesterone and deoxycort...

ea0070aep841 | Reproductive and Developmental Endocrinology | ECE2020

Androgens in women – the methods for their determination

Duskova Michaela , Kolatorova Lucie , Starka Luboslav

Four androgens are routinely measured in women: dehydroepiandrosterone sulfate (DHEAS), dehydroepiandrosterone (DHEA), androstenedione, and testosterone. The diagnosis of hyperandrogenemia in women is accompanied by many difficulties. One of them is the method used to measure androgens in the laboratory. In most laboratories, androgens are determined using various immuno-analytical methods. Recently, gas or liquid chromatography combined with mass spectrometry have begun to be...

ea0020p496 | Obesity and Metabolism | ECE2009

Influence of finasteride treatment on metabolic profile of men with androgenetic alopecia

Duskova Michaela , Hill Martin , Starka Luboslav

Androgenetic alopecia, not only caused psychological distress, but also is the risk factor of cardiovascular diseases, glucose metabolism disorders, benign prostate hyperplasia and prostate carcinoma and suspected to present the sign of male equivalent of polycystic ovary syndrome. Finasteride, used for treatment of androgenetic alopecia in dose of 1 mg/day, is the first 5α-reductase type II inhibitor. The 5α-reductase is enzyme responsible for the reduction of testo...

ea0016p20 | Adrenal | ECE2008

Diagnostic potential of GC--MS urinary steroid profiling in the diagnosis of CAH due to 21-OH deficiency in neonates and infants

Hartmann Michaela , Felszeghy Eniko , Wudy Stefan

21-hydroxylase deficiency is by far (>90%) the most common cause of congenital adrenal hyperplasia (CAH). Undiagnosed and untreated 21-hydoxylase deficiency bears the risk of salt loss, adrenal insufficiency and sex misassignment, therefore early diagnosis is very important. The most common way to identify children affected by the enzyme defect is the measurement of blood levels of adrenal hormones and precursor steroids, which is an invasive method and may lead to inaccur...

ea0035p949 | Steroid metabolism and action | ECE2014

The role of steroid hormones in the development of postpartum depression

Duskova Michaela , Mikesova Michaela , Jirak Roman , Hill Martin , Parizek Antonin , Starka Luboslav

Introduction: Postpartum depression affects 10–15% women after childbirth. There is no currently generally accepted theory about the causes and mechanisms of postpartum mental disorders. The principal hypothesis concerns the association with sudden changes in the production of hormones affecting the nervous system of the mother and, on the other hand, with the ability of receptor systems to adapt to these changes.Methods: We observed changes in ster...

ea0063gp130 | Obesity | ECE2019

Glucagon activity in human adipose precursors

Trabucco Martina , Cantini Giulia , Mannucci Edoardo , Luconi Michaela

Obesity is associated with increased and dysfunctional white adipose mass. In the past, pharmacological approaches have not yielded significant results in terms of stable weight loss. Glucagon-like peptide 1 receptor (GLP-1R) agonists (GLP-1RA) used for the treatment of type 2 diabetes have more recently been proposed as anti-obesity drugs due to their relevant effects on weight loss. Furthermore, dual agonists engaging both GLP-1R and glucagon receptor (GCGR) are under invest...

ea0049ep625 | Diabetes therapy | ECE2017

Sense of coherence and glycaemic control among a sample of newly diagnosed type II diabetics in rural Crete

Anyfantakis Dimitrios , Anyfantakis Anastasios , Foukaki Michaela , Kastanakis Serafim

Aim: Currently there is much discussion on the protective effects of the sense of coherence (SOC) on health. Our aim was to examine possible associations between SOC and glycemic control among 60 newly diagnosed adults with type 2 diabetes.Methods and results: Thirty males and 30 females diagnosed 3 months before with type 2 diabetes mellitus were included in the study. SOC was measured with the Greek translated and validated version of Antonovsky’s...