Searchable abstracts of presentations at key conferences in endocrinology

ea0011p555 | Growth and development | ECE2006

Significance of neonatal steroid imprinting and of peripubertal growth hormone excess for the development of prostatic hyperplasia in the rat

Goetz F , Mitroshkin A , Patchev AV , Rohde W

The benign prostatic hyperplasia (BPH) represents an enlargement of the epithelial and fibromuscular parts of the prostate. Although androgens per se do not cause BPH, an intact androgen metabolism is a prerequisite for the normal fetal and pubertal development of the prostate. Furthermore, growth factors play a role in the development of BPH. Animal experiments have shown that the prostate – similar to other organs of the reproductive tract – undergoes a neonatal st...