Searchable abstracts of presentations at key conferences in endocrinology

ea0029p923 | Female Reproduction | ICEECE2012

Frequency of insulin resistance, assessed by the glucose clamp technique, in 132 PCOS women

Tosi F. , Di Sarra D. , Zambotti F. , Dall'Alda M. , Donati M. , Moretta R. , Peroni M. , Signori C. , Caruso B. , Spiazzi G. , Bonin C. , Bonora E. , Moghetti P.

Introduction: Insulin resistance is a common finding in women with polycystic ovary syndrome (PCOS) and is considered a major aspect in this condition, as it likely plays a role in the pathogenesis of both hyperandrogenism and several metabolic abnormalities, frequently found in these women. Despite its significance, prevalence of insulin resistance in PCOS subjects is still unclear, as it was assessed in small samples and/or by using surrogate parameters of insulin action. Mo...

ea0029p1038 | Male Reproduction | ICEECE2012

Mutations and polymorphism of FSH and LH receptors and sperm quality in men with hypergonadotropic hypogonadism without obvious testicular noxa

Di Cairano G. , Cantara S. , Collodel G. , Moretti E. , Taglianetti S. , Mazzi L. , Pacini F.

Introduction: Inactivating mutations in LH or FSH receptors (R) are known causes of gonadotrophins resistance.Aim: This study aims at evaluating the presence of mutations and polymorphisms of FSHR and LHR and sperm quality in men with hypergonadotropic hypogonadism without obvious testicular noxa.Patients and methods: We selected 8 males with elevated levels of FSH and/or LH and normal levels of testosterone. Sperm parameters were ...

ea0029p1413 | Pituitary Clinical | ICEECE2012

Incidence of hypogonadism and evaluation of its impact on cardiovascular risk factors and quality of life in acromegalic patients

Rebora A , Nazzari E. , Malpassi D , Moretti S , Goglia U , Boschetti M , Minuto F , Ferone D

Acromegaly and hypogonadism represent independent cardiovascular risk factors, worsening either different metabolic parameters or quality of life (QoL).In our cohort of 41 acromegalic males (20–82 years), 35 resulted affected by hypogonadotropic hypogonadism, while only six were eugonadal. Twenty-nine out 35 had low testosterone levels at diagnosis and six developed a post-surgical hypogonadism (testosterone cut-off: 350 ng/dl). Among hypogonadal su...

ea0014p122 | (1) | ECE2007

Effect of surgery on carotid vascular remodeling in patients with pheochromocytoma

Bernini Giampaolo , Galetta Fabio , Bardini Michele , Franzoni Ferdinando , Taurino Chiara , Moretti Angelica , Bernini Matteo , Salvetti Antonio

In vitro and in vivo studies suggest that catecholamines, in addition to their hemodynamic effect, exert a direct influence on the vascular wall, leading to eutrophic and hypertrophic remodeling. This finding is in agreement with that recently reported by our group on patients with pheochromocytoma (PHEO) who show carotid intima media thickness (IMT) and vascular fibrosis higher than essential hypertensives matched for classic cardiovascular risk factors, includi...

ea0070aep1092 | Hot topics (including COVID-19) | ECE2020

Cholesterol and Graves’ Orbitopathy (GO): ‘A new decision-making algorithm based on baseline low density lipoprotein cholesterol (LDLc) and early GO clinical response to parenteral corticosteroids’

Naselli Adriano , Moretti Diletta , Regalbuto Concetto , Luisa Arpi Maria , Logiudice Fabrizio , Frasca Francesco , Belfiore Antonino , Le Moli Rosario

Introduction: Parenteral corticosteroids (PC) are effective for the treatment of active moderate to severe (AMS) Graves’orbitopathy(GO). A correlation of GO activity with cholesterol has been described. No evidences are available about cholesterol levels and the clinical efficacy of PC in AMS-GO.Aim: Was to detect the predictive role of cholesterol on medium term clinical outcome of PC therapy in AMS-GO.Methods: We studied 87...

ea0029p1580 | Thyroid (non-cancer) | ICEECE2012

The role of surgery in the treatment of amiodarone-induced thyrotoxicosis (AIT)

Tomisti L. , Materazzi G. , Marchello A. , Moretti M. , De Napoli L. , Brogioni S. , Miccoli P. , Bogazzi F. , Martino E.

Introduction: AIT develops in 15–20% of patients receiving amiodarone. Patients with persistent thyrotoxicosis or those with instable cardiac function, may be candidate for thyroidectomy; however, thyrotoxicosis and underlying cardiovascular disease may increased surgical risk.Matherials and methods: We retrospectively selected 23 AIT patients treated with a total thyroidectomy, from January 2000 to December 2010 [19 men, 4 women; mean (+SD), age 61...

ea0029p1750 | Thyroid cancer | ICEECE2012

Indoleamine 2,3-dioxygenase 1 (IDO1) and thyroid carcinoma: Ret/PTC appears as a strong genetic determinant for IDO1 expression

Menicali E. , Moretti S. , Voce P. , Melillo R. , Sponziello M. , Filetti S. , Avenia N. , Santoro M. , Puxeddu E.

Indoleamine 2,3-dioxygenase 1 (IDO1) is a single chain oxidoreductase that catalyzes tryptophan degradation to kynurenine. In cancer, it appears to exert an immunosuppressive function as part of an acquired mechanism of immune escape. In view of this notion, IDO1 has started to be considered a novel target in cancer therapy. Objective of this study was to evaluate IDO1 expression in papillary thyroid carcinoma (PTC) and to correlate its expression with genetic determinants of ...

ea0011p692 | Reproduction | ECE2006

Aldosterone and renin plasma levels in young patients with polycystic ovary syndrome

Bernini GP , Bela S , Cionini R , Bardini M , Moretti A , Benelli E , Rinaldi E , Burelli A , Vitti P , Pucci E

Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder in women of reproductive age often associated with insulin resistance, diabetes mellitus, hyperandrogenism, dislipidemia, obesity and hypertension, pathological conditions predisposing to high cardiovascular risk. Insulin resistant subjects may have higher plasma renin activity and it is well known that aldosterone plays a well-recognized role in the pathophysiology of hypertension and in the development of...

ea0081p31 | Calcium and Bone | ECE2022

Application of Calcium to Phosphorus (Ca/P) ratio in the diagnosis of pseudohypoparathyroidism: Another piece in the puzzle of diagnosis of Ca-P metabolism disorders

De Vincentis Sara , Brigante Giulia , Del Sindaco Giulia , Moretti Antonio , Pagnano Angela , Zirilli Lucia , Rochira Vincenzo , Simoni Manuela , Mantovani Giovanna , Madeo Bruno

Introduction: The serum calcium/phosphorus (Ca/P) ratio has been proposed to identify patients with primary hyperparathyroidism and chronic hypoparathyroidism (HPT) from healthy subjects. However, other disorders of the Ca-P metabolism might present similar biochemical profile of HPT, such as pseudohypoparathyroidism (PHP), for which the use of Ca/P can be useful. Aim: To test the performance of Ca/P ratio in the diagnosis of PHP in comparison to healthy...

ea0049oc9.5 | Thyroid Disease 2 | ECE2017

Selenium supplementation in the management of thyroid autoimmunity during pregnancy: results of the ‘Serena Study’ a randomized, double-blind, placebo-controlled trial

Dato Carla Di , Mantovani Giovanna , Moretti Costanzo , Greco Ermanno , Bonomi Marco , Faggiano Antongiulio , Di Sante Stefania , Giannetta Vincenzo , Petrone Luisa , Fumarola Angela , Colao Annamaria , Lenzi Andrea , Isidori Andrea M. , Giannetta Elisa

Autoimmune thyroiditis and related complications represent a growing concern during pregnancy. Selenium is frequently present in nutraceuticals recommended for thyroiditis and pregnancy, given its advocated role in immunity, fertility and thyroid function. However, most evidences come from non-controlled studies. Materials and MethodsWe designed a multicenter, randomized, double-blind, placebo-controlled trial (Serena Study: NCT01465867) to evaluate the ...