Endocrine Abstracts

The aim: To study case of partial gigantism.Methods: To evaluate the patient’s condition we conducted hormonal and biochemical investigations, as well as total blood and clinical urine analysis; Doppler sonography and multislice computed tomography were performed.Results: STH – 25.8 mIU/l (normal range: 2.0–20 mIU/l); IGF – 2.9 mg/l (normal range for the age: 13–100 mg/l); ALPase – 160 U/l (normal rang...

The aim: To study the case of Pachydermoperiostosisis.Material and methods: We report a case of a 24-year old male complaining of marked changes in appearance due to the disfiguring thickening and wrinkling of skin, excessive greasiness and perspiration, marked horizontal creases on the forehead, with deep furrows between them, increase in the thickness of eye lids, “senile expression” of the face, thickening of distal parts of extremities, fin...

Aim: To study features of family inheritance in patients of non-functional pituitary adenomas (NFPA) in Uzbekistan.Materials and methods: We included 71 patients with NFPA, intrasellar localization (mean size >3 mm). Mean age was from 18 to 70 years old (range 44.5±3.85 years). Of 71 patients, 30 (42.3%) were men and 41 (57.7%) were women.All patients underwent clinical and biochemical evaluations including endocrine check...

Background: Incorporating the ideas and views of children and young people (CYP) with endocrine conditions from early stages in the research life cycle will increase the benefit for patients and contribute to high impact research.Methods: We conducted two days of patient and public involvement (PPI) sessions with patients from a tertiary endocrine centre who are living with Congenital Adrenal Hypoplasia (CAH). We explore...

Background: Thyroid nodules (TN) are common. Their prevalence increases with age. A thyroid incidentaloma (TI) is defined as a non-palpable TN detected fortuitously during a radiological investigation performed for reasons unrelated to the thyroid gland. Although they are mostly benign, the risk of malignancy is estimated from 7% to 15% of nodules. The objective of this study is to investigate the characteristics of TI in a cohort of patients admitted in an internal medicine d...

Introduction: Retinal vein occlusions (RVO) are a heterogeneous group of disorders characterized by impaired venous return from retinal circulation. RVO can be classified into branch retinal vein occlusion (BRVO), hemiretinal vein occlusion (HRVO), and central retinal vein occlusion (CRVO) depending on the site of the obstruction. Major risk factors for BRVO include systemic arterial hypertension, arteriosclerosis, and diabetes, although many associations have been reported in...

Introduction: Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disease with heterogeneous presentation. SLE can be associated with autoimmune diseases or other entities sush as neuroendocrine tumors (NET). The occurrence of gastric NET in SLE is very rare and has been described few times in the literature. Herein we report the case of SLE woman, in whom we discovered a gastric neuroendocrine tumor. Observation: A 68-year-old woman, ...

Background: Anterior pituitary insufficiency or anterior hypopituitarism is a defect in the secretion of one or more of the pituitary hormones (ACTH, TSH, FSH and LH, GHand prolactin). It is a rare condition. A variety of diseases may be the cause, the most common being adenoma. In rare cases, it can be a clinical presentation of metastatic disease. Herein, we describe a case of a pituitary metastasis revealing a lung carcinoma in a 61-year old man.Case ...

Background: Anti-synthetase syndrome (ASS) is an idiopathic inflammatory myopathy (IIM). Clinical features may include myositis, interstitial lung disease (ILD), non-erosive arthritis, Raynaud’s phenomenon, and mechanic’s hands with the presence of anti-synthetase antibodies. Although ASS-neoplasia association has been reported, it remains scarce and debated association. Herein, we report an original case of thyroid carcinoma in a patient followed for ASS.<p clas...

Background: Well-differentiated GEP NETs show positive uptake on Ga-68-DOTATOC PET/CT, a somatostatin-receptor (SSTR)-specific imaging tracer. 18F-FDG PET/CT is preferred for aggressive, high-grade NETs as GLUT (glucose-transporter) receptor expression entails poorer prognosis. Grade 2 NET may demonstrate heterogenous uptake of both tracers; suggestive of tumor heterogeneity. PRRT is widely available at reasonable cost since Lu-177-DOTATATE is manufactured indegenously, and is...