Searchable abstracts of presentations at key conferences in endocrinology

ea0012p18 | Clinical case reports/Governance | SFE2006

Acromegaly with normal pituitary

Murthy PN , Davies PH

A 51 yr old woman presented to ENT surgeons with nasal polyps. Since examination revealed a multi-nodular goitre, large hands and prognathism, acromegaly was suspected. MRI of the pituitary arranged, was normal. Two years later, nasal polyps returned. CT on this occasion showed evidence of polyps with sinusitis but again a normal pituitary fossa. She was referred to a rheumatologist for carpal tunnel symptoms, the features of acromegaly were rediscovered and she was referred t...

ea0019p16 | Bone | SFEBES2009

Familial hypocalciuric hypercalcaemia and pregnancy outcome

Murthy A , Murthy NPN , Ashawesh K , Kulambil Padinjakara RN , Anwar A

Introduction: Hypercalcaemia during pregnancy poses a risk to both the mother and foetus and can present a complex management issue. Although hypercalcaemia from any cause can occur during pregnancy, primary hyperparathyroidism is the most common cause but other rarer cause such as familial hypocalciuric hypercalcaemia (FHH) should be ruled out. Although usually posing no risk to the mother, infants of mothers with the disease are at risk for neonatal hypocalcaemia, and seizur...

ea0062p72 | Poster Presentations | EU2019

Challenges in managing a young lady with recurrent unexplained hypoglycaemia

Robbins Tim , Murthy Narasimha , Gholap Nitin

Case history: A 23-year-old Caucasian nurse presented with six months of frequent recurrent symptomatic hypoglycaemic episodes with capillary blood glucose ranging between 1.2 and 3.5 mmol/l and symptoms improving after a carbohydrate snack or a drink. The episodes were more likely to occur during fasting state and after excess physical activities. A careful history excluded intake of any off-prescription medications, dfrugs or psychosocial problem.Inves...

ea0034p11 | Bone | SFEBES2014

Unusual cause of hypocalcemia

Pelluri Lavanya , Hariman Christian , Murthy Narasimha

Introduction: We present a rare cause of hypoparathyroidism and hypocalcemia and implications of the same during pregnancy.Case report: A 22-year-old primigravida was referred to the antenatal endocrine clinic with a longstanding history of hypoparathyroidism with hypocalcaemia. She had short stature and extended digits relative to her height. She has been taking alfacalcidol 0.5 μg once a day and adcal D3 tablets and blood tests revealed low normal...

ea0010p22 | Clinical case reports/Governance | SFE2005

Poems from the endocrinologist

Yemparala M , Murthy T , Fiad T

A 42 year old lady was referred to the endocrine clinic with a five month history suggestive of hypothyroidism and a high TSH and low T4 levels. Clinical examination revealed increased skin pigmentation, low systemic blood pressure, bilateral axillary lymphadenopathy and hepatosplenomegaly. Short synacthen test confirmed cortisol insuffiency and she was started on thyroxine and hydrocortisone, and went on to have further investigations for the lymphadenopathy and hepatosplenom...

ea0019p259 | Pituitary | SFEBES2009

Pituitary diseases and arachnoid cysts: more than a coincidence?

Murthy NPN , Murthy A , Ashawesh K , Kulambil Padinjakara RN , Pua S , Randeva H

CASE 1: A 50-year-old male was referred to the endocrine clinic with decreased libido and erectile dysfunction. Physical examination showed normal sense of smell, testicular size and secondary sexual characters. Investigations revealed low testosterone (10.6 mmol/l), SHBG 29.6 nmol/l, LH (6 IU/l) and FSH (7 IU/l) with high prolactin (4000 mU/l). The rest of the anterior pituitary hormones were normal. A MRI scan of the head showed a pituitary microadenoma with arachnoid cyst i...

ea0086op6.4 | Endocrine Cancer and Late Effects | SFEBES2022

Endocrinopathies in cancer patients receiving immune checkpoint inhibitors are associated with an improved overall survival

Murthy Sruthi , Mahmoud Sarah , Gonzalez Michael A , Martin Niamh M

Background: Immune checkpoint inhibitors (ICIs) including programmed-death cell-1 (PD-1), programmed death-ligand 1 (PD-L1) and cytotoxic T-lymphocyte antigen-4 (CTLA-4) re-activate T lymphocytes and promote cancer cell death. Immune-related adverse events (irAEs) are common in cancer patients receiving ICIs. Endocrine irAEs include primary thyroid dysfunction, hypophysitis, type 1 diabetes mellitus (T1DM) and primary adrenal insufficiency. These endocrinopathies may require a...

ea0065p66 | Adrenal and Cardiovascular | SFEBES2019

Waterhouse–Friderichsen syndrome: an endocrine emergency

Gatdula Erneda Reyes , Cho Sanda , Rao Ranganatha , Murthy Narasimha

Waterhouse–Friderichsen Syndrome is adrenal gland failure due to adrenal haemorrhage. It is an uncommon but usually life-threatening condition, which can be one of the serious complications of severe sepsis. Clinical manifestations of adrenal haemorrhage can vary widely depending on the degree and rate of haemorrhage. Adrenal haemorrhage may result from trauma, sepsis, anticoagulation medication, coagulopathy, autoimmune conditions, underlying tumour or idiopathic disease...

ea0039p3 | (1) | BSPED2015

The relationship between catch up growth and adipokine profile in adolescent children born preterm

Wood Claire , Korada Murthy , Mann Kay , Cheetham Tim , Embleton Nicholas

Background: Data remain conflicting regarding the long-term metabolic consequences of prematurity and the impact of early nutrition and catch-up growth. Adiponectin and leptin are adipocyte derived proteins (adipokines) and are thought to be important regulators of insulin action.Objectives: i) To investigate the influence of infant growth and contemporary body composition on adolescent adipokine secretion.ii) To investigate the co...

ea0028p2 | Bone | SFEBES2012

A case of HPT-JT syndrome with mutation involving exon 2 of CDC73 gene

Rao Ranganatha , Sivaraman Subash , Harrold Christopher , Murthy Narasimha , Sankar Sailesh

Background: Primary Hyperparathyroidism - Jaw tumour (HPT-JT) syndrome is an autosomal dominant disorder characterised by hyperparathyroidism and ossifying jaw fibromas. Inactivating germline mutations in CDC73 gene (previously known as HRPT2) is the main cause of this syndrome. There is higher incidence of parathyroid carcinoma in these individuals and also an association with other renal lesions have been described. We report a case of HPT-JT syndrome with mutation in the ex...