Searchable abstracts of presentations at key conferences in endocrinology

ea0011p678 | Reproduction | ECE2006

Changes in GnRH gene expression in the medial basal hypothalamus of rhesus macaques across the menstrual cycle

Urbanski HF , Noriega N , Garyfallou VT , Downs JL , Kohama SG

Rhesus macaques, like humans, express two molecular forms of gonadotropin-releasing hormone (GnRH-I and GnRH-II). Although the role of GnRH-I in the control of the reproductive axis is well-established, the physiological role of GnRH-II is less clear. Both forms of GnRH are highly expressed in the monkey hypothalamus and both forms are highly effective at stimulating LH and FSH release in vivo. However, estradiol appears to affect GnRH-I and GnRH-II gene expression diff...

ea0065oc1.6 | Metabolism and Obesity | SFEBES2019

Metabolic surgery reduces kidney SGLT2 expression in mice

Akalestou Elina , Noriega Livia Lopez , Chabosseau Pauline , Leclerc Isabelle , Rutter Guy

Background: Both metabolic surgery and sodium glucose co-transporter (SGLT2) inhibitors have been demonstrated to improve insulin sensitivity and glucose clearance, but also increase glucagon secretion and cardiovascular health.Aim: To examine the effect of metabolic surgery (Vertical Sleeve Gastrectomy; VSG) on SGLT2 expression in kidney cortex of lean mice.Methods: In order to assess whether exogenous SGLT2 inhibition has the sam...