Endocrine Abstracts

For a long time it has been suggested that glucocorticoids (GC) mediate their effects solely on the genomic level. A number of studies reported an existence of rapid GC effects independent on gene expression. These effects may play an important role in stress response or during acute GC therapy. As far as we know, rapid inhibitory GC effects on glucose-induced secretion of insulin have been reported only in animals (1). The aim of our study was to evaluate effects of GC on ear...

Background: Multiple sclerosis (MS) is a chronic inflammatory autoimmune and neurodegenerative disease of the central nervous system typically affecting young adults. Autonomic dysfunction is commonly detected in patients with multiple sclerosis. Lower response of sympathoadrenal system to various stressors is mainly connected with more developed disease. However, data evaluating sympathoadrenal system function in early MS are limited. Present study investigates stress respons...

Increased activity of sympathetic nervous system (SNS) was observed in early stage of hypertension onset. The aim of our present study was to estimate catecholamines response to stress stimulus (insulin induced hypoglycaemia) in young males with early diagnosed non-treated hypertension grade 1 (HT) and normotensive controls (NT).Methods: Insulin tolerance test (ITT, 0.1 IU/kg body weight, Actrapid HM, i.v.) was performed in 21 HT male subjects aged 20.0&...

Context: The interpretation of low-dose ACTH test during endogenous and exogenous hypercortisolemia induced by stress and glucocorticoid therapy in critically ill patients with possible relative adrenal insufficiency.Objective: The hypothesized inhibitory effects of hypercortisolemia on adrenal responsiveness in humans were tested using two model situations in low-dose ACTH testing.Subjects and methods: Nine young healthy women und...

Objective: Increased abdominal visceral adipose tissue (VAT) deposition is associated with insulin resistance in obese and/or hypertensive patients. We investigated the association of insulin sensitivity with the amount of VAT in young, lean, non-treated males with recently established high normal blood pressure or hypertension grade 1 (HT).Subjects and methods: Twenty-one subjects with HT (age 20.3±0.6 years, BMI 22.4±0.5 kg/m2, sys...

Objective: Changes of hypothalamic-pituitary-adrenal (HPA) axis activity, in particular decreased production of adrenal androgens, have been observed in patients with rheumatic diseases. However, data on adrenal steroid status in patients with psoriatic arthritis (PsA) are scarce. The present study was aimed at evaluation of HPA status in context of chronic inflammation in glucocorticoid-naïve premenopausal females with PsA.Subjects and methods: Con...

Hypothyroidism is associated with modest weight gain, but there is a lack of clarity regarding subclinical hypothyroidism and obesity. Studies with bariatric surgery showed that 15–25% of extremely obese subjects had subclinical hypothyroidism. Therefore the goal of this study was to evaluate the effect of intensified life style intervention on insulin sensitivity, irisin concentration and thyroid function parameters.Methods: A randomized i...

Adult GH deficiency (GHD) is associated with prediabetes and low levels of GH are found in obesity. We hypothesized that zinc-α2-glycoprotein (ZAG), a novel adipokine reduced in obesity, is regulated by GH. ZAG serum and adipose tissue expression were measured in three study populations: i) cachectic (BMI=19.3±0.5 kg/m2), lean/overweight (BMI=26.0±0.5 kg/m2) and obese (BMI=36.0±1.6 kg/m2) patients with chronic obstructive pu...

The role of adipokines and inflammatory cytokines of adipose tissue for development of the growth hormone deficiency (GHD)-related metabolic derangements has not yet been completely understood. Therefore, we screened the protein level of 120 adipokines in subcutaneous adipose tissue (ScAT) of patients with GHD in adulthood.Subjects and methods: Sixteen GHD (10M/6F) with BMI 27±1.0 kg/m2, age 30±2 yrs and sixteen controls matched for ...

Growth hormone deficiency (GHD) in adults seems to predispose to insulin resistance (IR). Development of GHD related IR could be associated with adipose tissue (AT) derived signals. To investigate the nature of this pathological regulation we 1) measured gene expressions for leptin, adiponectin, TNFalpha, IL-6, 11beta HSD1, SREBP, PPARgamma in the AT of untreated GHD adults, and 2) assessed effect of euglycemic hyperinsulinemia (HI) at the gene level.Met...