Endocrine Abstracts

The importance of the Liver X receptors (LXRs) as a critical modulators of metabolic homeostasis and immunity in health and disease has been mainly gleaned from studies evaluating the consequences of their pharmacological or genetic manipulation. We previously showed LXRα is phosphorylated upon cholesterol loading. It is however unknown whether post-translational modifications of the receptor modulate diet-induced responses and affect metabolic diseases with an important ...

Introduction: Medullary thyroid cancer is a rare neoplasm, accounting for approximately 4% of all cases of thyroid cancer. Exceptionally, it can be associated with the hormonal production of ACTH or CRH, causing ectopic Cushing’s syndrome.Clinical Case: We present the case of a 43-year-old man who, as a history of interest, presented a T6-T8 vertebral body fracture 2 years ago and a right hip fracture 1 year ago. Bone densitometry is compatible with...

Background: Non-alcoholic fatty liver disease (NAFLD) is a spectrum of progressive liver diseases driven in part by macrophages, occurring in the absence of excessive alcohol consumption that ranges from simple steatosis to non-alcoholic steato-hepatitis (NASH), ultimately progressing to fibrosis/cirrhosis and hepatocellular carcinoma. NAFLD is associated with insulin resistance and confers an increased risk of cardiovascular disease. Pre-menopausal women are protected against...

Introduction: Adequate iodine intake is important in pregnant women.Objective: To determinate iodine status and thyroid volumen (TV) in healthy pregnant women from Navarra (Spain), and to evaluate possible influence of diet.Methods: A cross-sectional study of 144 women in the first trimester of pregnancy (single pregnancies) was carried during 2014. We measured thyroid-stimulating hormone (TSH), free thyroxine (fT4) and antithyroid...

Objective: Immune checkpoint inhibitors (ICPI) have become an effective therapeutic option for certain advanced malignant tumours. Immune-related adverse events affecting thyroid function are among the most frequent toxicities. The aim of our study is to determine the prevalence of thyroid disorders in patients undergoing treatment with ICPI.Methods: Retrospective study including all patients treated with ICPI in our centre, from 07/2015 to 12/2017. Pati...

Serum thyroglobulin (Tg) is a biomarker used to assess iodine nutrition status, but data in pregnant women are scarce.Objectives: To determine serum Tg concentration in Spanish healthy pregnant women, and to evaluate its relation with yoduria (UIC), thyroid volume, iodine intake and thyroid function throughout pregnancy.Methods: Longitudinal study in pregnant women with no history of thyroid disease, recruited in 2 obstetric center...

Background: Insulin resistance and ageing are risk factors for the development of type 2 diabetes and atherosclerosis. Insulin signalling in macrophages affects their inflammatory responses and foam cell formation capacity, yet the mechanisms linking these remain unclear. Recent evidence has emerged linking macrophage lipid metabolism and inflammatory response such as an interferon-cholesterol pathway flux axis. Insulin has been shown to directly regulate chol...

Authors 1-4 contributed equally to this work.Background: Insulin resistance is the central defining feature of type 2 diabetes and increases with age. People with type 2 diabetes are at an increased risk of cardiovascular disease, non-alcoholic fatty liver disease (NAFLD), Alzheimer’s disease and arthritis. Macrophages are phagocytotic leukocytes which play a central role in the development of type 2 diabetes and the chronic inflammatory di...

Evidence on whether neonatal thyroid screening results are dependent on maternal thyroid function is limited.Objectives: To study the relationship between iodine status and maternal thyroid function in pregnancy, and neonatal screening results in a Northern Spanish population.Methods: Prospective, longitudinal study of 297 pregnant women recruited in 2 obstetric centers of Pamplona (Spain) at the first antenatal visit, and their ne...

Neuromedin U (NMU) is a brain-gut peptide originally isolated from porcine spinal cord, and later found in other species. NMU acts through two receptors named NMU1R (abundant in peripheral tissues) and NMU2R (apparently restricted to specific brain regions). Besides its potential implication in the control of stress responses, NMU is abundantly expressed in the ventromedial hypothalamic area and has been involved, as satiety factor, in the regulation of food intake. Very recen...