Searchable abstracts of presentations at key conferences in endocrinology

ea0011oc57 | ThyroidOC57 British Thyroid Association Award | ECE2006

Treatment of experimental hyperthyroid Graves’ disease with decoy TNF-family ligand receptors, suggests an essential role for BAFF in production of thyroid stimulating antibodies

Gilbert JA , Kalled SL , Moorhead J , Hess D , Rennert P , Li Z , Khan Z , Banga J-P

Introduction and Aims: GravesÂ’ disease (GD) is mediated by thyroid stimulating antibodies (TSAbs) to the TSH receptor (TSHR). Treatments for GD have remained unchanged for more than 40 years with less than 50% of patients achieving long term remission with medical therapy. Experimental animal models have been described which facilitate understanding of disease mechanisms and permit studies of novel immunotherapeutic interventions. However studies aiming to perturb the Th1...