Endocrine Abstracts

Objective: To determine the progression rate to impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and diabetes (DM2) and risk factors of progression to diabetes in normal glucose tolerant (NGT) people during 8 years follow up study using WHO 1999 criteria and new criteria of IFG (IFG 5.6-fasting glucose 5.6–6.9 mmol/l).Research design and methods: This is an 8 year prospective observation in a randomly selected urban population aged ...

Objective: To determine the progression rate to impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and diabetes (DM2) in normal glucose tolerant (NGT) people during 8 years follow up using WHO 1999 criteria and new criteria (IFG-fasting glucose 5.6–6.9 mmol/l).Research design and methods: This is an eight year prospective study in a randomly selected urban population aged >=40 years living in Krakow, Poland. 1752 persons had NGT.b...

Introduction: Among three types of gastric neuroendocrine tumors (GEPNETV) type 1 are most common. At the basis of the pathogenesis of type 1 is atrophic gastritis, which leads to achlorhydria and deficiency of intrinsic factor, resulting in G cell hyperplasia and hypergastrinaemia. Gastric endoscopy usually reveals the multiple and polypoid lesions (<1–2 cm) in the corpus. Five-year survival in these patients is not different from survival in the selected age group p...

Objective: To determine the predictive risk factors for the development of type 2 diabetes mellitus (DM) in patients with impaired glucose tolerance (IGT) or impaired fasting glucose (IFG) during the 8.5 follow up.Research design and methods: This is an 8-year prospective study in a randomly selected urban population including 2838 subjects aged ≥40 years living in Krakow. Seven hundred and six had IGT (387) or IFG (319) based on WHO criteria and 2...

Aim: Aim of the study was to assess the effectiveness of the structured lifestyle intervention in diabetes type 2 high risk people.Methods: The De-Plan Project participants were selected based on FINDRISK over 14. Exclusion criteria were known or OGTT diabetes. Intervention completed by 175 participants consisted of 10 group sessions on lifestyle changes, diet and physical activity education, and 6 telephone motivation sessions and voluntary physical act...

Introduction: Mutation in PROP1 gene is the cause of different forms of pituitary dysfunction. The assessment of the functioning of the adrenal axis still raises the most doubts.Aim& methods: A retrospective longitudinal (mean 35 years, SD 16.24) analysis of 32 patients (19W/13M, including 5 families and sporadic cases) with PROP1 mutation was performed to define the optimal diagnostic approach in evaluation of adrenal axis. In the study morning cort...

Introduction: Extended up to 20 years follow-up of several randomised control trials showed 34–43% diabetes risk reduction. Real life implementation studies performed worldwide in different settings and populations proved that also non-intensive, low budget lifestyle interventions can be effective. However little is known about long-term results of the translational studies.Objective: To study the risk factors changes of the DEPLAN non-intensive lif...

Introduction: The mode of pituitary function deterioration in patients with PROP1 mutation is not fully known and understood. The function of adrenal axis requires special attention.Aim: To investigate the time/mode/markers of pituitary function deterioration in families/sporadic patients with PROP1 mutation during longitudinal observation.Methods: We performed retrospective longitudinal (36.4 years, s.d. = 13.6) analy...