Searchable abstracts of presentations at key conferences in endocrinology

ea0032p346 | Diabetes | ECE2013

Elevation of circulating free fatty acids abolishes down-regulation of skeletal muscle adiponectin receptor 1 (AdipoR1) expression caused by insulin infusion

Straczkowski Marek , Karczewska-Kupczewska Monika , Adamska Agnieszka , Stefanowicz Magdalena , Matulewicz Natalia , Kowalska Irina , Nikolajuk Agnieszka

Introduction: Adiponectin is an adipocytokine with insulin-sensitizing and anti-inflammatory properties. In skeletal muscle, it increases fatty acid oxidation and insulin-stimulated glucose uptake through binding with adiponectin receptor 1 (AdipoR1). The aim of our study was to assess the effect of insulin and Intralipid/heparin infusions on muscle AdipoR1 expression in humans.Methods: Twenty healthy male subjects (age 25.2±3.2 years; BMI, 26.5&#17...

ea0032p351 | Diabetes | ECE2013

Skeletal muscle and adipose tissue glycoprotein 130 expression is associated with insulin resistance in humans

Karczewska-Kupczewska Monika , Nikolajuk Agnieszka , Adamska Agnieszka , Matulewicz Natalia , Stefanowicz Magdalena , Kowalska Irina , Straczkowski Marek

Introduction: Glycoprotein 130 (gp130) cytokines, like interleukin 6 (IL6), act through plasma membrane receptors consisting of two glycoproteins: a cytokine binding subunit (like IL6R) and gp130, responsible for signal transduction. IL6 may regulate insulin sensitivity in a dual manner, as both insulin-sensitizing and -desensitizing actions have been reported. Other gp130 cytokines may have a beneficial metabolic effects. The aim of the present study was to assess skeletal mu...

ea0032p735 | Obesity | ECE2013

Serum IL18 concentration is associated with resting energy expenditure independently of BMI

Nikolajuk Agnieszka , Adamska Agnieszka , Karczewska-Kupczewska Monika , Matulewicz Natalia , Stefanowicz Magdalena , Kowalska Irina , Straczkowski Marek

Introduction: Numerous studies indicate an association between low-grade chronic inflammation and predisposition to type 2 diabetes and atherosclerosis. IL18 is a proinflammatory cytokine with proatherogenic properties. Existing evidence indicated that circulating IL18 was associated with insulin resistance, metabolic syndrome and type 2 diabetes. Some data suggest that endogenous IL18 signaling modulates food intake, metabolism and adiposity, as homeostatic regulator. The aim...

ea0029p534 | Diabetes | ICEECE2012

Suppressive effect of hyperinsulinemia on serum interleukin 18 concentration in young healthy subjects

Straczkowski M. , Karczewska-Kupczewska M. , Adamska A. , Nikolajuk A. , Matulewicz N. , Zielinska M. , Gorska M. , Kowalska I.

Introduction: Interleukin 18 (IL-18) is a proinflammatory and proatherogenic cytokine which is associated with obesity, insulin resistance and cardiovascular disease. It is supposed that insulin has anti-inflammatory action. The aim of the present study was to estimate serum IL-18 concentration in young healthy population, its regulation by hyperinsulinemia and relationship with insulin sensitivity and glucose and lipid oxidation.Methods: We studied 36 h...

ea0029p643 | Diabetes | ICEECE2012

The impact of hyperinsulinemia on the serum IL12p40 subunit concentration

Nikolajuk A , Adamska A , Karczewska-Kupczewska M , Matulewicz N , Zielinska M , Gorska M , Kowalska I , Straczkowski M

Introduction: Numerous studies indicate an association between low-grade chronic inflammation and predisposition to type 2 diabetes and atherosclerosis. IL12 is a proinflammatory cytokine with proatherogenic properties. IL12 is a disulfide-linked, 70 kDa (p70) heterodimeric glycoprotein composed of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit. Many data reported higher levels of p40 subunit than total IL12. The aim of the present study was to investigate the influence of ...

ea0029p1141 | Neuroendocrinology | ICEECE2012

Circulating interleukin 6 and soluble forms of interleukin 6 receptor and glycoprotein 130 in women with anorexia nervosa

Karczewska-Kupczewska M. , Kowalska I. , Nikolajuk A. , Adamska A. , Otziomek E. , Gorska M. , Straczkowski M.

Introduction: Anorexia nervosa (AN) is an eating disorder, resulting in sustained low weight and marked decrease in fat mass. Interleukin 6 (IL-6) may play a role in appetite, energy expenditure and body weight control in central nervous system. IL-6 acts through binding with membrane receptor (IL-6R) and activates glycoprotein 130 (gp130) signaling. Both IL-6R and gp130 are present in the blood in the soluble forms (sIL-6R and sgp130, respectively). sIL-6R sensitizes cells to...

ea0022p345 | Diabetes | ECE2010

Decreased serum brain-derived neurotrophic factor concentration in young nonobese subjects with low insulin sensitivity

Karczewska-Kupczewska Monika , Adamska Agnieszka , Nikolajuk Agnieszka , Otziomek Elzbieta , Gorska Maria , Straczkowski Marek , Kowalska Irina

Insulin resistance and type 2 diabetes are associated with an increased risk of neurodegenerative diseases. Brain-derived neurotrophic factor (BDNF) regulates neuronal differentiation and synaptic plasticity and its decreased levels are supposed to play a role in the pathogenesis of Alzheimer disease and other disorders. Decreased circulating BDNF levels in obesity and type 2 diabetes were reported, however, it is unclear, whether BDNF might be associated with insulin resistan...

ea0020p446 | Obesity and Metabolism | ECE2009

Serum visfatin concentration in obesity and impaired glucose tolerance – relationship with insulin resistance, blood pressure and proinflammatory factors

Kowalska Irina , Straczkowski Marek , Nikolajuk Agnieszka , Karczewska-Kupczewska Monika , Adamska Agnieszka , Gorska Maria

Visfatin, a protein secreted by the adipose tissue, might regulate insulin action. The aim of the present study was to assess serum visfatin concentration in obese women with normal glucose tolerance (NGT) and impaired glucose tolerance (IGT) and to estimate the relationships between serum visfatin concentration and insulin sensitivity, blood pressure, proinflammatory and proatherogenic factors.The study group consisted of 134 women: 30 overweight or obe...

ea0020p481 | Obesity and Metabolism | ECE2009

Relationships of TNFα system with glucose and lipid oxidation in subjects with different degree of insulin sensitivity

Adamska Agnieszka , Karczewska-Kupczewska Monika , Kowalska Irina , Nikolajuk Agnieszka , Gorska Maria , Straczkowski Marek

One of the key actions of insulin is the regulation of glucose and lipid oxidation. Disturbances in substrate oxidation play an important role in the development of insulin resistance. Insulin action is inversely associated with circulating pro-inflammatory cytokines such as soluble TNF-α receptors (sTNFR1 and sTNFR2).The aim of the present study was to analyze the associations between serum sTNFR1 and sTNFR2 concentrations and glucose and lipid oxi...

ea0020p500 | Obesity and Metabolism | ECE2009

Normal metabolic flexibility despite insulin resistance in lean and obese women with polycystic ovary syndrome

Straczkowski Marek , Kowalska Irina , Adamska Agnieszka , Karczewska-Kupczewska Monika , Nikolajuk Agnieszka , Lebkowska Agnieszka , Gorska Maria

Polycystic ovary syndrome (PCOS) is heterogeneous disorder, where insulin resistance might be involved in the development of endocrine and metabolic abnormalities. Insulin resistance is associated with the so-called metabolic inflexibility i.e. an impaired switch from lipid to glucose in response to insulin. The aim of the present study was to estimate glucose and lipid oxidation, metabolic flexibility and non-oxidative glucose metabolism in lean and obese PCOS patients.<p...