Searchable abstracts of presentations at key conferences in endocrinology

ea0016p154 | Clinical cases | ECE2008

Serious hypocalcemia as the first display of coeliac disease of the Down syndrome patient

Semanova Zuzana , Telepkova Danica , Tajtakova Maria , Zakuciova Maria

The coeliac disease is the autoimmunity disease of small intestine, which is the immune response result to various proteins of cereals, especially wheat gliadin. in adulthood it often manifests with various symptomatology, which includes metabolic osteopathy arising on secondary hyperparathyreosis.There is casuistic model of 24-year-old patient with Down syndrome and documented autoimmunity thyroiditis, where the coeliac disease manifested by serious hyp...

ea0016p270 | Endocrine disruptors | ECE2008

Serum level of vitamin A, transthyretine and retinol binding protein in a region polluted by polychlorinated biphenyls in a long term

Semanova Zuzana , Tajtakova Maria , Petrasova Darina , Rosenberger Jaroslav

Vitamin A (retinol) plays a non-substitutable role in a process of growth and differentiation of tissues. Deficit of retinol can be encountered at its long-term diet deprivation (primary deficit), but it can occur also as a consequence of metabolism disorders on various levels (secondary deficit). Secondary deficit of retinol can occur also in people exposed to chemical substances in the long term or people living in an environment polluted by chemicals for a long time. One of...

ea0011p241 | Cytokines and growth factors | ECE2006

Effect of growth hormone deficiency in adults on insulin action and gene expression of selected adipokines in subcutaneous adipose tissue

Penesova A , Skopkova M , Pura M , Vlcek M , Radikova Z , Vorzakova I , Tajtakova M , Vanuga P , Belan V , Koska J , Payer J , Klimes I , Gasperikova D

Growth hormone deficiency (GHD) in adults seems to predispose to insulin resistance (IR). Development of GHD related IR could be associated with adipose tissue (AT) derived signals. To investigate the nature of this pathological regulation we 1) measured gene expressions for leptin, adiponectin, TNFalpha, IL-6, 11beta HSD1, SREBP, PPARgamma in the AT of untreated GHD adults, and 2) assessed effect of euglycemic hyperinsulinemia (HI) at the gene level.Met...