Searchable abstracts of presentations at key conferences in endocrinology

ea0011p648 | Reproduction | ECE2006

Plasma endothelin-1 levels in patients with male hypogonadism

Tomova A , Kumanov Ph , Kirilov G

Endothelin-1 has various paracrine and endocrine effects on the male reproductive system. It is supposed that the testosterone is probably responsible for the higher endothelin-1 levels in males and this may be related with the enhanced cardiovascular risk in males of reproductive age. In order to study in more detail the relationship between endothelin-1 and testosterone, we have studied 37 male patients with various forms of hypogonadism (14 with hypergonadotrophic hypogonad...

ea0016p520 | Obesity | ECE2008

Changes of the testosterone levels in young males with obesity and metabolic syndrome

Robeva Ralitza , Kirilov Georgi , Tomova Analia , Kumanov Philip

Aim: The present study aimed to compare the androgen levels in men with obesity, metabolic syndrome /MS/ and healthy normal – weight controls.Materials and methods: Eighty-six males (mean age 29.65±8.57 /18–50/) were investigated. 31 of them were healthy (mean BMI – 23.66±1.97); 22 were with simple obesity (mean BMI – 32.79±7.16) and 33 (mean BMI – 35.78±8.71) were with overt metabolic syndrome /MS/ according ...

ea0016p617 | Reproduction | ECE2008

Anti-Mullerian hormone levels in women with polycystic ovary syndrome before and after metformin therapy

Tomova Analia , Robeva Ralitza , Kumanov Philip , Kirilov Georgi , Mechandjiev Zvetozar

Recently was established, that in the ovary Anti-Müllerian hormone (AMH) is produced by the granulose cells and correlated with the count of small antral follicles. As AMH is largely expressed throughout folliculogenesis, it is considered that the serum levels of AMH may represent both the quantity and quality of the ovarian follicle pool. To determine the changes of AMH in women with polycystic ovary syndrome (PCOS) we have studied 22 patients with this disorder and comp...

ea0022p459 | Female reproduction | ECE2010

CAG repeat polymorphism in women with PCOS and healthy controls

Robeva Ralitsa , Dobreva Desislava , Kirilov Georgi , Mechandjiev Tcvetosar , Tomova Analia , Savov Aleksey , Kumanov Filip

The androgen receptor (AR) polymorphism is determined by a variable number of CAG triplets in exon 1 of the AR gene, located on the X chromosome. CAG polymorphism could modulate different hyper- or hypoandrogenic conditions, but its influence on the polycystic ovarian syndrome (PCOS) in different ethnic populations is controversial. Therefore, we investigated the influence of the AR polymorphism on the hormonal factors and clinical signs in 52 women with PCOS and in 41 non-hir...

ea0022p460 | Female reproduction | ECE2010

CAG repeat polymorphism in healthy women

Robeva Ralitsa , Dobreva Desislava , Kirilov Georgi , Tomova Analia , Savov Aleksey , Kumanov Filip

Androgen receptor (AR) containes a variable polyglutamine chain that is determined by the different number of CAG repeats in the AR gene on the X chromosome. The transactivational competence of AR is inversely related to the length of the polyglutamine chain, respectively to the CAG repeat number. Therefore, we investigated the role of the androgen receptor polymorphism in healthy hirsute and non hirsute women.CAG repeat length polymorphism was analyzed ...

ea0016p621 | Reproduction | ECE2008

Semen quality in men with obesity and metabolic syndrome

Robeva Ralitza , Sestrimska Nina , Atanasova Iliana , Tomova Analia , Kirilov Georgi , Kumanov Philip

Aim: The aim of the study was to compare the semen quality in men with metabolic syndrome/MS/ and healthy controls.Materials and methods: Semen samples were collected from 35 males (mean age – 27.45±8.00 years). Nineteen of them had the features of the metabolic syndrome according to the IDF definition and 16 were healthy volunteers. The semen samples were analyzed by only one experienced researcher according to the World Health Organization gu...