Searchable abstracts of presentations at key conferences in endocrinology

ea0014p376 | (1) | ECE2007

Increase of L-thyroxine requirement during pregnancy

Russo Laura , Tonacchera Massimo , Gianetti Elena , Vitti Paolo , Pinchera Aldo

In pregnant women with a thyroid disease an increased amount of LT4 may be required for the correction of hypothyroidism or treatment of nodular goiter.Aim of this study was to assess the amount of the variations of LT4 requirement in pregnant women with thyroid diseases.To address this issue, we retrospectively evaluated a cohort of 138 women treated with LT4 divided in two groups: 47 euthyroid (E) (affected by nodular goiter (NG)...

ea0014p377 | (1) | ECE2007

Safety of pharmacological treatment of thyroid diseases &br;during pregnancy

Gianetti Elena , Tonacchera Massimo , Russo Laura , Vitti Paolo , Pinchera Aldo

Pregnant women may require treatment of hypo- or hyperthyroidism, L-thyroxine (LT4), propylthiouralcil (PTU) and methimazole (MMI) being the most frequently used drugs. Aim of this study was to verify the consequences of pharmacological treatment during pregnancy. We retrospectively evaluated 379 pregnancies: 124 patients under MMI treatment, 35 of whom still hyperthyroid in spite of treatment (H-MMI) and 89 euthyroid (E-MMI); 52 GD patients under PTU, 20 of whom still hyperth...

ea0011p829 | Thyroid | ECE2006

Safety of pharmacological treatment of thyroid diseases during pregnancy

Gianetti E , Tonacchera M , Russo L , Perri A , Vitti P , Pinchera A

Pregnant women may require treatment of hypo- or hyperthyroidism, L-thyroxine (LT4), propylthiouralcil (PTU) and methimazole (MMI) being the most frequently used drugs. Aim of this study was to verify the consequences on both the mother and the fetus of pharmacological treatment during pregnancy. We retrospectively evaluated 292 pregnancies: 63 patients under MMI treatment, 8 of whom (7 GravesÂ’ (GD) and 1 toxic nodular goiter) still hyperthyroid in spite of treatment (H-M...

ea0011p830 | Thyroid | ECE2006

Increase of L-thyroxine requirement during pregnancy

Russo L , Tonacchera M , Gianetti E , Perri A , Vitti P , Pinchera A

In pregnant women with thyroid diseases an increased amount of LT4 may be required for the correction of hypothyroidism or treatment of nodular goiter. Aim of this study was to assess the amount of the variations of LT4 requirement in pregnant women with thyroid diseases. To address this issue, we retrospectively evaluated a cohort of 107 women treated with LT4 divided in two groups: 42 euthyroid (E) (affected by nodular goiter (NG) treated with LT4 suppressive therapy) and 65...

ea0029p1611 | Thyroid (non-cancer) | ICEECE2012

Frequency of PDE8B gene polymorphisms in patients affected by sporadic and familiar nonautoimmune subclinical hypothyroidism

Agretti P. , Ferrarini E. , De Marco G. , Dimida A. , Molinaro A. , Niccolai F. , Pinchera A. , Vitti P. , Tonacchera M.

Background: Nonautoimmune subclinical hypothyroidism is characterized by elevated serum levels of TSH in the presence of normal thyroid hormone levels and absence of anti-thyroid antibodies. As a result of a genomic-wide study, a strong association between three polymorphic variants in exon 1 of human phosphodiesterase 8B (PDE8B) gene (rs4704397, rs6885099 e rs2046045) and serum levels of TSH has been recently reported. The aim of the present study was to evaluate the frequenc...

ea0056p1024 | Thyroid (non-cancer) | ECE2018

Post partum and non-post partum relapsing Graves’ hyperthyroidism display different response to anti-thyroid drugs

Capelli Valentina , Rotondi Mario , Coperchini Francesca , Pinto Sara , Croce Laura , Tonacchera Massimo , Chiovato Luca

Background: GravesÂ’ disease (GD) female patients in remission after a full course of methimazole (MMI) therapy are at risk for a relapse of hyperthyroidism during the post-partum (PP) period, but whether this relapse may display any peculiarity is still unknown.Aim: To compare GD patients undergoing a relapse of hyperthyroidism either in the PP period or not.Subjects and methods: Fourty-three female patients of childbearing ag...

ea0092ps3-23-05 | Pregnancy | ETA2023

Iodine nutritional status and related thyroid function in pregnancy: A results of a prospective study conducted in a large group of women

Sciarroni Elisabetta , Orsolini Francesca , Gianetti Elena , Montanelli Lucia , Bagattini Brunella , Fiore Emilio , Tonacchera Massimo

Background and Objectives: During pregnancy normal thyroid activity undergoes significant changes, including an increase in the amount of iodine intake and maternal renal iodine excretion. Hence, dietary iodine requirements are higher in pregnant women than in non-pregnant ones. This study aimed to assess the nutritional iodine status in a large group of pregnant women and thyroid function according to different iodine intake and thyroid diseases.Methods...

ea0081p701 | Reproductive and Developmental Endocrinology | ECE2022

Evolution of congenital hypothyroidism with in situ thyroid gland in children and adolescents

Pignata Luisa , Bagattini Brunella , Montanelli Lucia , Agretti Patrizia , De Marco Giuseppina , Ferrarini Eleonora , Orsolini Francesca , Tonacchera Massimo

Background: In recent years, increasing cases of congenital hypothyroidism (CH) with in situ thyroid gland are identified. Outcome of children affected from CH with normally sited thyroid of normal size is still unknown. The objective of our study is to describe the natural history of this specific form of CH. Patients and methods: We retrospectively evaluated clinical, biochemical and instrumental data of 74 patients with diagnosis of CH with in situ thyroid...

ea0084ps1-02-15 | Hypothyroidism | ETA2022

Use of iodine in the treatment of congenital hypothyroidism with an in situ thyroid gland and of non-autoimmune subclinical hypothyroidism

Pignata Luisa , Montanelli Lucia , Bagattini Brunella , Sciarroni Elisabetta , Agretti Patrizia , De Marco Giuseppina , Ferrarini Eleonora , Tonacchera Massimo , Di Cosmo Caterina

Introduction: Congenital hypothyroidism (CH) with in situ thyroid gland (GIS) and non-autoimmune subclinical hypothyroidism (NASI) are functional defects of thyroid gland occurring at birth and after birth, respectively. In recent years, a higher incidence of these disorders has been documented. The etiology remains unclear, with only an almost 50% of cases attributable to mutations in known dyshormonogenesis-associated or TSH-receptor genes. Although replacement ther...

ea0084ps1-02-16 | Hypothyroidism | ETA2022

Evolution of congenital hypothyroidism with in situ thyroid gland in children and adolescents: Clinical and biochemical features at diagnosis and after retesting

Bagattini Brunella , Agretti Patrizia , De Marco Giuseppina , Ferrarini Eleonora , Orsolini Francesca , Sciarroni Elisabetta , Tonacchera Massimo , Montanelli Lucia , Pignata Luisa

Background: In recent years, increasing cases of congenital hypothyroidism (CH) with in situ thyroid gland (GIS) are identified. Outcome of children affected from CH with normally sited thyroid of normal size is still unknown. The objective of our study is to describe the natural history of this specific form of CH.Methods: We retrospectively evaluated clinical, biochemical and instrumental data of 89 patients with diagnosis of CH and GIS, refer...