Searchable abstracts of presentations at key conferences in endocrinology

ea0070s8.2 | PCOS: from Genetics to Treatment | ECE2020

Estroprogestins and female sexuality

Vignozzi Linda

Estroprogestins (EP) are the short-acting hormonal contraceptives most commonly used in Europe, and include combined oral contraceptives (COCs), the patch, and the vaginal ring. Although the safety and efficacy of EP have being extensively investigated, scarce and controversial evidence is available on their impact on female sexuality. The potential negative effects of EP on female mood and desire are hypothesized to derive from sex steroids altering the interplay between neur...

ea0090p725 | Reproductive and Developmental Endocrinology | ECE2023

The Role of Testosterone Treatment in Patients with Type 2 Diabetes Mellitus: Results from A Meta-Analysis Study

Vena Walter , Vignozzi Linda , Maggi Mario , Sforza Alessaandra , Pizzocaro Alessandro , Corona Giovanni

Introduction: type 2 diabetes mellitus (T2DM) and hypogonadism are common conditions afflicting the aging male, often present together. The specific role of testosterone (T) replacement therapy (TRT) on glycometabolic profile and body composition, particularly in patients with T2DM, is still the object of an intense debate. The aim of the present study is to meta-analyze the role of TRT in T2DM considering all placebo and non-placebo-controlled randomized clinical trials (RCTs...

ea0049gp147 | Male Reproduction and Endocrine Disruptors | ECE2017

Effects of physical exercise or metformin on testosterone deficiency and erectile dysfunction associated to metabolic syndrome

Vignozzi Linda , Filippi Sandra , Comeglio Paolo , Cellai Ilaria , Corcetto Francesca , Corno Chiara , Maggi Mario

Metabolic Syndrome (MetS) is a cluster of clinical conditions, associated to an increased cardiovascular and metabolic risk, to hypogonadism and erectile dysfunction (ED). Lifestyle modification (including physical exercise, PhyEx) and metformin (MET) are well-known treatments for the condition. We established an animal model of MetS that recapitulates the human phenotype, including andrologic derangements.The aim of this study was to investigate in expe...

ea0049ep377 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

The dual FXR/TGR5 agonist INT-767 counteracts nonalcoholic steatohepatitis and visceral adipose tissue dysfunction in a rabbit model of high fat diet-induced metabolic syndrome

Comeglio Paolo , Cellai Ilaria , Filippi Sandra , Morelli Annamaria , Sarchielli Erica , Adorini Luciano , Maggi Mario , Vignozzi Linda

The nuclear Farnesoid X receptor (FXR) and the G protein-coupled bile acid receptor 1 (TGR5) are bile acids receptors that play a key role in energy metabolism. In an animal model of non-genomic metabolic syndrome (MetS), obtained with a high fat diet (HFD), treatment with the dual FXR/TGR5 agonist INT767 reduced visceral adipose tissue (VAT) accumulation, insulin resistance, hypercholesterolemia and nonalcoholic steatohepatitis (NASH). In liver, INT767 reduced the high macrop...

ea0041gp187 | Reproduction & Endocrine Disruption | ECE2016

Testosterone supplementation and body composition: results from a meta-analysis of observational studies

Corona Giovanni , Giagulli Vito A , Maseroli Elisa , Vignozzi Linda , Aversa Antonio , Zitzmann Michael , Saad Farid , Maggi Mario

Background: The concept of testosterone (T) supplementation (TS) as a new anti-obesity medication in men with testosterone deficiency syndrome (TDS) is emerging.Aim: To systematically review and meta-analyze available observational and register studies reporting data on body composition in studies on TS in TDS.Methods: An extensive Medline Embase and Cochrane search was performed including the following words: ‘testosterone&#1...

ea0041ep204 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Testosterone supplementation and body composition: results from a meta-analysis of randomized controlled trials

Corona Giovanni , Giagulli Vito A , Maseroli Elisa , Vignozzi Linda , Aversa Antonio , Zitzmann Michael , Saad Farid , Maggi Mario

Background: The role of testosterone (T) in regulating body composition is conflicting.Aim: To meta-analyze the effects of T supplementation (TS) on body composition and metabolic outcomes.Methods: All randomized controlled trials (RCTs) comparing the effect of TS on different endpoints were considered.Results: Overall, 59 trials were included in the study enrolling 3029 and 2049 patients in TS and control gr...

ea0041ep212 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Which are the male factors associated with female sexual dysfunction (FSD)?

Maseroli Elisa , Fanni Egidia , Mannucci Edoardo , Fambrini Massimiliano , Jannini Emmanuele A , Maggi Mario , Vignozzi Linda

It has been generally assumed that partner’s erectile dysfunction (ED), premature (PE) and delayed ejaculation (DE) play a significant role in determining Female sexual dysfunction (FSD). The present study aimed to evaluate the role of perceived male partner’s sexual function and of the referred quality of relationship in determining FSD. A consecutive series of 156 heterosexual women consulting our outpatient clinic for FSD between January and December 2014 was retr...

ea0035oc9.2 | Reproduction | ECE2014

Tadalafil ameliorates metabolic syndrome-induced alterations in visceral adipose tissue and liver: an experimental study in the rabbit

Vignozzi Linda , Filippi Sandra , Cellai Ilaria , Comeglio Paolo , Maneschi Elena , Galli Andrea , Maggi Mario

Visceral adipose tissue (VAT) dysfunction is closely associated with the rising incidence of cardiovascular diseases (CVD) and type 2 diabetes mellitus. Two distinct types of adipose tissue, white (WAT) and brown (BAT), are present in mammals. Development of ‘brown-like’ adipocytes within white adipose tissue has potential antiobesity and insulin-sensitizing effects. Genetic manipulation of cGMP formation suggests a new role for this pathway in preadipocytes commitme...

ea0035p691 | Male reproduction | ECE2014

Clinical correlates of enlarged prostate size in subjects with sexual dysfunction

Corona Giovanni , Maseroli Elisa , Ratrelli Giulia , Vignozzi Linda , Forti Gianni , Maggi Mario

Introduction: Digito-rectal examination (DRE) of the prostate is provides useful information on the state of prostate growth and on the presence of suspected peripheral nodules. The aim of this study is to describe the clinical and biochemical correlates of finding an enlarged prostate size at DRE in subjects with sexual dysfunction (SD).Methods: A consecutive series of 2379 patients was retrospectively studied. The analysis was focused on a subset of su...

ea0035p693 | Male reproduction | ECE2014

Seminal, ultrasound and psychobiological parameters correlate with metabolic syndrome in male members of infertile couples

Lotti Francesco , Corona Giovanni , Degl'Innocenti Selene , Filimberti Erminio , Scognamiglio Vittoria , Vignozzi Linda , Forti Gianni , Maggi Mario

Introduction: Metabolic syndrome (MetS) is a diagnostic category which identifies subjects at high risk for diabetes and cardiovascular diseases, erectile dysfunction (ED) and male hypogonadism. However, MetS impact on male infertility has been poorly studied. We systematically evaluated possible associations between MetS and clinical characteristics in men with couple infertility.Methods: Out of 367 consecutive subjects, 351 men (36.0±8.0 years) wi...