Endocrine Abstracts

Premature ovarian insufficiency (POI) is defined as hypergonadotropic oligo/amenorrhoea with FSH>40 IU/l, estradiol <50 pmol/l in women under 40 years of age. Biological aging is faster in this group of women inducing diseases and disturbing quality of life.Infertility in POI represents a special issue. Hypoestrogenism, hypoprogesteronism, hypoandrogenism, decreasing of dehydroepiandrosteron sulfate, growth hormone, and increasing insulin resistance influence all body ...

The aim of the study was to assess the role of the estradiol and progesterone relationship during the late luteal phase and the occurrence of fibrocystic breast disease (FBD). The concentration of E2/P was measured in the group of women with FBD as study group and healty control group. All women had regular ovulation cycles. Blood samples for E2, P and prolactin determination were obtained in the morning at 8 am on days 21 and 24 of menstrual cycle. Significant mastalgia and m...

Introduction: The average age for physiological menopause is 50 years. Menopause before the age of 40 is usually defined as premature ovarian failure (POF). POF in adolescents is an extremely rare event and its occurrence raises important questions about the cause-and-effect relationship, which may signal genetic and systemic disorders.Design Case report: The 29-year-old first reported to an endocrinologist for secondary amenorrhea. The anamnesis reveale...

Aim: To present a patient with all manifestations of long-term unsubstituted hypothyroidism-from alopecia to myxedema megacolon.Case: Sixty-one-old year women was admitted in ICU due to disturbance of consciousness, respiratory failure and electrolyte imbalance. Sopor, expressed alopecia, dry, flaky, pail skin, generalized edema, lung stasis and pericardial friction. A laboratory parameters pointed to the presence of normocytic normochromic anemia, hypon...

Background: Individuals with gender incongruence receive gender affirming therapy which is fundamental to sex reassignment. Cross sex hormone treatment both improves and impairs several surrogate markers of cardiovascular risk. In the aging population of transsexual persons, we are called to address clinical endpoints of the long-term gender affirming hormone therapy.Aim: Aim was to assess changes in the fasting serum lipid profile during gender affirmin...

Introduction: There is a significant overlap of symptoms between polycystic ovary syndrome (PCOS) and thyroid disease, despite the fact that they are two different diseases. Both diseases individually affect a woman’s metabolic parameters and fertility, and their association makes them much more difficult to manage.Objective: To investigate the effect of elevated thyroid stimulating hormone (TSH) concentrations on metabolic and endocrine parameters ...

Introduction: A rare cause of adrenal incidentaloma is congenital adrenal hyperplasia (CAH). Nonclassic CAH is one of the most frequent autosomal recessive disorders. Most cases of nonclassic CAH are never diagnosed due to very mild symptoms.Case report: A 62-year-old woman admitted at our Department for right adrenal incidentaloma sized 39×34×38 mm confirmed by MRI. She was asymptomatic. Her past medical history included stabile hypertension, ...

Introduction: Central obesity is the source of inflammatory factors, causing endothelial dysfunction. In central nervous system, inflammatory factors mediate neurotransmitter metabolism promoting excitotoxicity and increase oxidative stress, and a major clinical symptom is depression. Mediterranean diet (MD) resulted as a good prevention method for depression.Aim: To examine the relationship of depression with abdominal obesity and metabolic syndrome (MS...

Introduction: In adults, the most common cause of obstructive sleep apnoea is obesity. Other causes are anatomical craniofacial bony abnormalities, neurologic syndromes, alcohol and sedatives use, hypothyroidism, acromegaly and rarely thyroid goitre. Untreated obstructive sleep apnoea can lead to serious complications, including cardiovascular diseases, accidents, and premature death.Case report: A 56-year-old patient was referred to a pulmologist due to...

Introduction: Primary thyroid lymphoma (PTL) presents between 2 and 8% of all thyroid malignancies. Rapidly enlarging neck mass, especially in women with Hashimoto’s thyroiditis should steer the diagnostic procedures in the way of PTL. The most common type is diffuse large B-cell lymphoma. Adrenal incidentaloma are incidentally discovered adrenal masses without prior suspicion of adrenal disease.Case report: A 71-year-old woman with an adrenal incid...