Searchable abstracts of presentations at key conferences in endocrinology

ea0077p235 | Reproductive Endocrinology | SFEBES2021

Wilms’ Tumour-1 (WT1) regulates proliferation, apoptosis and endocrine function in a model of human granulosa cells

Watson Lucy , Childs Andrew

Background: The Wilms’ Tumour-1 (WT1) transcription factor is a critical regulator of embryonic gonadogenesis, but is also expressed by granulosa cells (GCs) in preantral follicles in the ovary after birth. Evidence from animal models suggests an important role for WT1 in regulating GC steroidogenesis and apoptosis. However, the role of WT1 in human GC biology has not been extensively explored.Aim: To investigate the role of WT1 in regulating human ...

ea0009p187 | Clinical | BES2005

Pituitary mass due to lymphocytic hypophysitis presenting in late pregnancy with spontaneous post-partum resolution

Watt A , Bidgood K , Watson J

Lymphocytic hypophysitis is a rare inflammatory disease of the pituitary gland. The aetiology is unknown though probably of autoimmune origin.We report the case of a 40 year-old woman who presented 39/40 weeks pregnant with an inferior bitemporal homonymous quadrantinopia. She had primary hypothyroidsim and had had previous unsuccessful in-vitro fertilisation, though this conception was spontaneous. Magnetic resonance imaging (MRI) demonstrated a large p...

ea0005p56 | Clinical Case Reports | BES2003

An occult cause of hirsutism

O'Mullane N , Watson A , Bannerjee B

A 64 year-old woman was referred because of male pattern baldness and hirsutism. There were no virilizing or Cushingoid features and no abnormalities on gynaecological assessment.Investigations: Testosterone 7.4 nmol/L [0-2.4], FSH 81.0 iu/L, LH 38.3 iu/L, 17 Alpha hydroxyprogesterone 11.0 nmol/L [0-10], Free androgen index 21.1 [0-7.5], DHEA sulphate 1.9 micromol/L [2.2-10.0], urine free cortisol less than 150 nmol/24 hrs. Chest x-ray normal, abdominal and pelvic ultrasou...

ea0086p156 | Adrenal and Cardiovascular | SFEBES2022

Whole genome sequencing and Sanger sequencing to identify novel mutations in adrenal tumours from cats with primary hyperaldosteronism

Watson Alice , Syme Harriet , Brown Morris

Primary Hyperaldosteronism (PA) is caused by adrenal tumours or bilateral adrenal hyperplasia (Djajadiningrat-Laanen et al., 2011) causing constitutive aldosterone production. Both germline and somatic mutations have been identified in human PA (Scholl, 2022). The commonest somatic mutations in benign tumours causing PA in humans include KCNJ5, CACNA1D, ATP1A1 and ATP2B3 (Williams et al., 2015). It is hypothesized that analogous somatic mutations arise in fel...

ea0011p112 | Clinical case reports | ECE2006

Three generations of generalised resistance to thyroid hormone (GRTH)

McGeoch SC , Watson WA , Stephen E , Watson H , Mayo A , Abraham P , Bevan JS

Background: Generalised Resistance to Thyroid Hormone (GRTH) is an autosomal dominant condition with impaired tissue responsiveness to thyroid hormones. The majority of patients are asymptomatic and compensate adequately by elevated thyroid hormone production.Index case: A 47-year-old woman was referred to the thyroid clinic in 2000 when routine thyroid function tests (TFT) showed elevated TSH at 4.9 mU/l and fT4 36 pmol/l. A TSH-oma was excluded by norm...

ea0090ep1006 | Thyroid | ECE2023

Severe symptomatic hypercalcaemia associated with thymic hyperplasia and mediastinal lymphadenopathy secondary to Graves’ Disease

Audet Samuel , Bujanova Jana , Ito, Adam Watson Erisa

Background: Hypercalcaemia of hyperthyroidism via increased bone turnover is not uncommon, however it is usually mild and asymptomatic. Corrected calcium (cCa) concentrations ≥ 3.0mmol/l are seen rarely and tend to be associated with high TSH receptor antibodies concentration. Some of the less well-known effects include thymic hyperplasia (TH) and lymphadenopathy. TH is explained by thyroid hormone acting on thyrotropin receptors in thymic tissue to increase proliferatio...

ea0065p354 | Reproductive Endocrinology and Biology | SFEBES2019

Maternal cardiovascular risk and pregnancy outcomes in turner syndrome – new evidence supports current guidance

Calanchini Matilde , Bradley-Watson James , Orchard Elizabeth , Turner Helen E

Introduction: The risk of maternal death from aortic-dissection(AoD) during pregnancy/post-partum in TS is increased, due to TS-associated risk factors (bicuspid-aortic-valve(BAV), aortic-coarctation, aortic-dilatation, hypertension) and the increased cardiovascular strain of pregnancy itself. TS-guidelines advice against pregnancy in the presence of severe aortic-dilatation or moderate dilatation with AoD-risk factors; and after aortic surgery a high risk remains. However, fe...

ea0066p44 | Diabetes 4 | BSPED2019

Treatment of paediatric diabetic ketoacidosis (DKA) with subcutaneous rapid-acting insulin: a UK centre, retrospective review of safety and efficacy data

Freund Katja , Logan Karen , Watson Mando , Wassouf Samir

Introduction: The British Society of Paediatric Endocrinology (BSPED) DKA guidelines endorse the use of subcutaneous (SC) insulin in clinically well patients. In our institution, routine practice is to use SC insulin to manage DKA patients, without clinical evidence of shock. We present safety and efficacy data.Methods: A retrospective review of electronic records was performed to identify episodes of DKA (pH <7.30 or HC03<18 mmol/l and ketonaemi...

ea0066p50 | Diabetes 5 | BSPED2019

Use of flash glucose monitoring during hypo/hyperglycaemia and to guide insulin administration in paediatric patients with type 1 diabetes

Jordan Kate , Bound Christopher , Vieira Soraia , Wassouf Samir , Watson Mando

Introduction: Flash glucose monitoring is increasingly used in the management of T1DM. Although the FreeStyle Libre reduces the overall burden of conventional self-monitoring of blood glucose, capillary glucose should be checked at times of Libre-predicted extreme hypo/hyperglycaemia.Methods: Consenting FreeStyle Libre users completed a structured questionnaire via phone interview. Users reported incidence of extreme hypo/hyperglycaemia (indicated by LO/...

ea0044ep56 | (1) | SFEBES2016

An Unusual case of a para-sellar mass

Kumar Ramesh , Surya Ashutosh , Dixon Anthony , Watson David

A 36 year-old female presented with increasing headaches over the previous 8 months. She had seen in the neurology clinic recently and treated for migraines and cluster headache. She also had a history of depression. She had prodromal aura of visual disturbance including blurred vision and photophobia.She was admitted following sudden onset of stabbing pain over the left eye along with nausea. All these symptoms were classic of her usual migraines. On ad...