Searchable abstracts of presentations at key conferences in endocrinology

ea0011p701 | Reproduction | ECE2006

Metformin therapy decreases hyperandrogenism and hyperinsulinaemia in women with polycystic ovary syndrome

Abdalla TME , Wilton D , Wilton A , Wayte A , Griffiths K , Huber J

Insulin resistance has been suggested to have a pathogenic role in polycystic ovary syndrome (PCOS). The use of insulin sensitising drugs might therefore have a therapeutic role in its management.We studied 20 patients (mean age 32.6 years) with PCOS (diagnosed by the Rotterdam Consensus Workshop group criteria, 2003) before and after treatment with metformin (1.5–3 grams daily) for 6 to 12 months.Clinical features studied wer...

ea0011p702 | Reproduction | ECE2006

A unique subgroup of patients with polycystic ovary syndrome identified by clinical and biochemical features

Abdalla TME , Wilton A , Wilton D , Griffiths K , Wayte A , Huber J

Hyperandrogenism of adrenal origin evidenced by elevated dehydroepiandrosterone sulphate (DHEAS) levels has been reported in 20% to 30% of patients with polycystic ovary syndrome.We studied 50 patients with PCOS (defined by the Rotterdam Consensus Workshop group criteria, 2003). Adrenal hyperandrogenaemia was defined as a DHEAS level> 10.5 micromoles/litre was found in 10 patients (20%). Clinical features studied were body mass index (BMI) and hirsut...

ea0015p82 | Clinical practice/governance and case reports | SFEBES2008

An audit of diagnosis and management of acromegaly in a District General Hospital

Khedr M , Abdalla TME , Wilton A

Acromegaly is a rare disorder which the Royal College of Physicians/Society for Endocrinology Guidelines-Pituitary Tumours (1997) suggest should be referred to a specialist centre if suspected. We audited the diagnosis and management of acromegaly in our unit (population covered 250 000) over a 10-year period (1997–2007). Twelve patients (6 male, 6 female), mean age 48.5 years (29–69) were confirmed as having acromegaly. The mean time from referral to first clinic vi...

ea0009p175 | Thyroid | BES2005

An audit of the outcome of a fixed dose (555Mbq)of radioidine for hyperthyroidism

Abdalla T , Khan S , Wilton A

BackgroundRadioiodine therapy (RAI) is an effective treatment for hyperthyroidism, being used with increasing frequency. There is no consensus as to the correct use of radioiodineThe aim is to compare our practice to the standards recommended by the working group of the Royal College of Physicians and Society for Endocrinology and to measure the outcome at one year of using a fixed dose of RAI (555 Mbq) .Meth...

ea0005p17 | Clinical Case Reports | BES2003

A novel DAX-1 gene mutation with adrenal hypoplasia congenita, differing degrees of hypogonadism and decreased bone mineral density

Abdalla T , Owen A , Curtis A , Wilton A

Mutations of the DAX-1 gene cause X-linked adrenal hypoplasia congenita and hypogonadotrophic hypogonadism. Two half brothers (same mother, different fathers) were diagnosed as having Addison's aged14 years (brother A) and 7 years (brother B). Their mother had haemochromatosis being homozygous for the Cys 282 Tyr mutation of the HFE gene. Both had delayed pubertal development but defaulted from follow up. Brother A re-presented at 29 years of age with infertility. In view of t...

ea0050ep008 | Adrenal and Steroids | SFEBES2017

Glucocorticoid and mineralocorticoid Insufficency on treatment with tramadol

Anthony Wilton , Shaikh Mansoor , Searell Katrin

A 30 year old female presented with recurrent episodes of collapse with hypotension. She had been taking tramadol 100 mg four times daily for pain due to endometriosis. A random cortisol of 110 nmol/L led to suspicion of opiate induced adrenal insufficiency and further investigations were undertaken. Results 09:00 hours ACTH 3.2 ng/L, cortisol 109 nmol/L, fT4 12.3 pmol/L, fT3 3.7 pmol/L, TSH 1.18 mU/L, FSH 6.8 IU/L, LH 12.1 IU/L, prolactin 438 mU/L a...

ea0050ep008 | Adrenal and Steroids | SFEBES2017

Glucocorticoid and mineralocorticoid Insufficency on treatment with tramadol

Anthony Wilton , Shaikh Mansoor , Searell Katrin

A 30 year old female presented with recurrent episodes of collapse with hypotension. She had been taking tramadol 100 mg four times daily for pain due to endometriosis. A random cortisol of 110 nmol/L led to suspicion of opiate induced adrenal insufficiency and further investigations were undertaken. Results 09:00 hours ACTH 3.2 ng/L, cortisol 109 nmol/L, fT4 12.3 pmol/L, fT3 3.7 pmol/L, TSH 1.18 mU/L, FSH 6.8 IU/L, LH 12.1 IU/L, prolactin 438 mU/L a...

ea0044cc1 | Featured Clinical Cases | SFEBES2016

Life threatening cardiac arrhythmias following treatment of newly diagnosed Addison’s disease

Rochester J , Aflorei ED , Roberts A , Wilton A

A 36 year old man presented with collapse following weakness and vomiting for 2 weeks and 7 kg weight loss over 6 months. Thyroxine 50 mcg OD had been commenced 2 months earlier for hypothyroidism (Free T4 9.4 pmol/l, TSH 8.4 mU/l and anti-TPO antibodies 103.1 IU/mL). Examination found cachexia (weight 53.6 Kg), vitiligo, sinus tachycardia 110 bpm and BP 90/66 mmHg. Investigations: sodium 115 mmol/l, potassium 4.4 mmol/l, urea 9.9 mmol/l, creatinine 81 μmol/l, cortisol 13...

ea0044cc7 | Featured Clinical Cases | SFEBES2016

Spurious diagnosis of phaeochromocytoma due to drug induced symptoms and abnormal investigation results

Preece R , Rochester J , Aflorei E.D , Wilton A

A 70 year old female was referred with a putative diagnosis of phaeochromocytoma. She was awaiting hiatus hernia surgery; the diagnosis was based on a history of hypertension and a persistent sinus tachycardia of 110 bpm. Investigations had shown modest elevation of 24 hour normetadrenaline at 4.71 to 4.98 micromol/24 hr (<4.4) on 3 occasions and plasma normetadrenaline of 2398 and 2504 pmol/l (<1180). Review of her medical records confirmed that the onset of tachycard...

ea0059ep12 | Adrenal and steroids | SFEBES2018

Loperamide induced hypoadrenalism presenting as recurrent hypoglycaemia in a patient with type 1 diabetes

Healy Jessica , Wayte Avril , Wilton Anthony

A 32 year old female presented with recurrent episodes of severe hypoglycaemia. Type 1 diabetes had been diagnosed 10 years earlier and she had undergone subtotal colectomy/ileostomy 20 months earlier for chronic diarrhoea. Histology suggestive of eosinophilic colitis. High stoma output (>4 litres per 24 hours) was causing stomal incontinence with disruption of normal lifestyle. Treatment with combinations of loperamide, codeine, omeprazole and octreotide were ineffective....