Searchable abstracts of presentations at key conferences in endocrinology

ea0014p643 | (1) | ECE2007

The clinical outcomes of stimulation of ovulation in patients with idiopathic hypogonadotropic hypogonadism (IHH) caused by mutations of GnRH receptor

Wolczynski Slawomir , Zbucka Monika , Jarzabek Katarzyna

We report pregnancies obtained after stimulation by gonadotropins in 3 patients with IHH caused by homozygous or compound heterozygous mutations of GnRH receptor: (R139H/R262Q, R139C/ R139C, R139H/ Phe 308 del.);Gonadotropin response to GnRH was observed in the first patient. All the patients were stimulated with gonadotrophins according to the protocole step up with the initial dose of 150IU FSH and 75 IU LH a day. The luteal phase was suported by hCG a...

ea0049ep1104 | Female Reproduction | ECE2017

Serum concentrations of betatrophin and its association with indirect indices of insulin resistance and beta cell function in women with polycystic ovary syndrome

Adamska Agnieszka , Lebkowska Agnieszka , Jacewicz Malgorzata , Krentowska Anna , Hryniewicka Justyna , Wolczynski Slawomir , Gorska Maria , Kowalska Irina

The accumulated data underline the role of betatrophin in glucose homeostasis. Polycystic ovary syndrome (PCOS) is characterized by insulin resistance and high risk of developing prediabetes and diabetes. The aim of our study was to investigate the relationship of serum betatrophin concentrations with indirect indices of insulin resistance and insulin secretion in women with PCOS, comparing to the control group. The study group comprised 43 women with PCOS and 16 controls matc...

ea0029p915 | Female Reproduction | ICEECE2012

Plasma anti-Müllerian hormone concentration in women with polycystic ovary syndrome and type 1 diabetes mellitus

Lebkowska A. , Karczewska-Kupczewska M. , Nikolajuk A. , Adamska A. , Otziomek E. , Wolczynski S. , Gorska M. , Kowalska I.

Introduction: A high prevalence of polycystic ovary syndrome (PCOS) and hyperandrogenism has been described in adult women with type 1 diabetes mellitus (T1DM). Anti-Müllerian hormone (AMH) is secreted by granulosa cells of antral ovarian follicles and its plasma concentration is correlated with the number of small antral follicles. AMH levels are increased in women with PCOS and higher plasma concentration has been observed in prepubertal girls with T1DM. The aim of this...

ea0011p249 | Cytokines and growth factors | ECE2006

Plasma interleukin 18 in patients with polycystic ovary syndrome – relation to insulin resistance

Kowalska I , Straczkowski M , Nikolajuk A , Kozlowska A , Karczewska-Kupczewska M , Adamska A , Wolczynski S , Kinalska I , Gorska M

Aim of the study: Polycystic ovary syndrome (PCOS) is common disease affecting women in reproductive age which leads to anovulation. In pathogenesis of PCOS insulin resistance plays an important role. The aim of the present study was to look for possible relationship between interleukin 18 (IL-18) and insulin resistance in patients with PCOS.Material and Methods: The study was done in 76 patients with PCOS and 40 women without menstrual disturbances. The...

ea0090oc4.3 | Oral Communications 4: Reproductive and Developmental Endocrinology | ECE2023

The association between selected serum microRNAs, adipokine concentrations, and body composition assessed with dual-energy X-ray absorptiometry in young women with polycystic ovary syndrome

Krentowska Anna , Ponikwicka-Tyszko Donata , Lebkowska Agnieszka , Adamska Agnieszka , Hryniewicka Justyna , Sztachelska Maria , Milewska Gabriela , Wolczynski Slawomir , Kowalska Irina

Introduction: Polycystic ovary syndrome (PCOS) is associated with an increased risk of abdominal obesity, what is regulated by numerous genetic, epigenetic, and environmental factors. MicroRNAs (miRNAs) are known regulators of gene expression, involved in the development of metabolic disturbances. Dual-energy X-ray absorptiometry (DXA) is an accurate method of body composition analysis. The aim of the present study was to investigate the association between circulating miRNAs,...

ea0041gp183 | Reproduction & Endocrine Disruption | ECE2016

Intima media thickness and brachial artery flow mediated dilatation in women with polycystic ovary syndrome and type 1 diabetes mellitus

Lebkowska Agnieszka , Adamska Agnieszka , Tolwinska Joanna , Jacewicz Malgorzata , Hryniewicka Justyna , Milewski Robert , Wolczynski Slawomir , Bossowski Artur , Gorska Maria , Kowalska Irina

Polycystic ovary syndrome (PCOS) and type 1 diabetes (T1DM) are accompanied by increased risk of atherosclerosis. A higher prevalence of PCOS in T1DM patients has been reported. Brachial artery flow-mediated dilatation (FMD) and intima media thickness of common carotid artery (IMT) are used to detect an early endothelial dysfunction.The aim of our study was to examine IMT and FMD in T1DM women with PCOS. We also estimated the relation of IMT and FMD to c...

ea0037gp.06.04 | Reproduction: Female and PCOS | ECE2015

Phenotypic characteristic of type 1 diabetic women with polycystic ovary syndrome

Lebkowska Agnieszka , Adamska Agnieszka , Karczewska-Kupczewska Monika , Nikolajuk Agnieszka , Otziomek Elzbieta , Milewski Robert , Wolczynski Slawomir , Gorska Maria , Kowalska Irina

Introduction: The prevalence of polycystic ovary syndrome (PCOS) is increased in women with type 1 diabetes (T1DM) in comparison to the general population. It has been suggested that exogenous insulin administered to T1DM women in supraphysiological doses could act as co-gonadotropin and lead to disturbances observed in PCOS.Aim: The aim of this study was to evaluate the phenotypic characteristic and differences between diabetic women with PCOS (T1DM+PCO...

ea0037gp.06.08 | Reproduction: Female and PCOS | ECE2015

Plasma brain derived neurotrophic factor is decreased in women with polycystic ovary syndrome and related to the markers of endothelial dysfunction

Kowalska Irina , Karczewska-Kupczewska Monika , Adamska Agnieszka , Nikolajuk Agnieszka , Lebkowska Agnieszka , Otziomek Elzbieta , Wolczynski Slawomir , Straczkowski Marek

Introduction: Brain derived neurotrophic factor (BDNF) is a neurotrophin which plays a role in neuronal growth and differentiation. Decreased level of BDNF is supposed to play a role in the pathogenesis of the neurodegenerative diseases. Recent data indicate that BDNF could be also involved in angiogenesis. Several lines of evidence support the role of BDNF in glucose metabolism. The decreased level of BDNF are observed in obesity and type 2 diabetes mellitus. Polycystic ovary...

ea0037gp.30.05 | Endocrine tumours and neoplasia – General | ECE2015

Targeted destruction of FSHR-positive cells by lytic peptide Phor21 conjugated with FSHβ subunit in vitro

Chrusciel Marcin , Stelmaszewska Joanna , Ponikwicka-Tyszko Donata , Doroszko Milena , Wolczynski Slawomir , Huhtaniemi Ilpo , Ziecik Adam , Rahman Nafis

FSH receptor (FSHR) expression has been shown in gonadal tumours, as well as in endothelial tumour vessel cells of various cancers. FSHR, due to its transmembrane localization could be a good candidate for receptor-mediated targeted cancer therapy. In recent years, a number of membrane disrupting lytic peptides have been used for receptor-based cancer therapy. In the present study, we characterised the specificity and cytotoxicity of a lytic peptide Phor21 conjugated to three ...

ea0035oc10.5 | Endocrine Tumours | ECE2014

Molecular mechanisms underlying the unexpected promoting effects of mifepristone on murine testicular Leydig cell tumorigenesis

Chrusciel Marcin , Ponikwicka-Tyszko Donata , Stelmaszewska Joanna , Li Xiangdong , Huhtaniemi Ilpo , Toppari Jorma , Wolczynski Slawomir , Rahman Nafis

Progesterone (P4) treatment has been shown to have a clear modulating effect on murine Leydig tumor cell (mLTC-1) function, including downregulation of luteinizing hormone receptor. We hypothesized that P4 would stimulate, whereas an antiprogestine mifepristone (MF) block tumor progression in vivo in a transgenic (TG) murine Leydig cell tumor model (inhibin-α promoter-driven SV40 T-antigen (inhα/Tag)) and act similarly on cell proliferation in vitro...