Endocrine Abstracts

Objective: We aimed to determine the risk of hypercalcemia in a geriatric population with very high dose levels of 25-hydroxy-vitamin D (25(OH)D)Patients and Method: This study was designed as a retrospective, cross-sectional two-center study for examining the elderly patients with very high 25(OH)D levels (>88ng/ml) between January 2014 and December 2019. After recruitment, subgroup analyses of the patients were performed based on their calcium and ...

Introduction: A successfull diabetes management is not only restricted to medical therapy but also includes a difficult and new life style adoptation. Errors frequently observed in patients such as not complying with their diet program, wrong way of doing insulin injections and insufficient insulin doses, hinder the adequate metabolic control of the disease. Also, physco-social status and different education levels complicate the effectiveness of the first training of the pati...

Objective: To determine the relationship between metabolic syndrome (MS) and cognitive decline in people over 60 years age.Methods: The age of the participants were between 60 and 89 years old (71.71±6.58). According to NCEP ATP III criteria 93 had MS and 47 had not. Cognitive performance was determined with the use of standardized mini mental test and the mini mental scores (MMS) of the two groups were compared. Apart from the MS we investigated th...

Aim: The aim was to assess the expressions of GLP-1, IGF-1 and leptin in the paraffin sections of operated thyroid cancer and non-thyroid cancer patients, and show the relationship of GLP-1, IGF-1 and leptin receptor expressions with thyroid cancer, comparatively.Materials and Methods: This study was carried out retrospectively. The case groups consisted of 20 medullary thyroid cancer (MTC), 20 follicular thyroid cancer (FTC), 20 classical papillary thyr...

Introduction: Although the syndrome of inappropriate antidiuretic hormone (SIADH) has connection with various malignant tumors, the pituitary metastasis of malignant tumors are generally associated with diabetes insipidus.Case report: A 59 years old male patient presented to emergency service with frequent syncope attacks, nausea, loss of appetite and fatigue that began 2 weeks prior to admission. Marked obtundation was found on physical examination. The...

Introduction: The results of publications investigating the relationship between low maternal serum 25-hydroxyvitamin D (25OHD) level and gestational diabetes mellitus (GDM) are controversial and none of these publications have investigated this relationship according to the severity of 25OHD deficiency. Therefore, this study was conducted to assess the relationship between low maternal serum 25OHD and GDM according to the severity of 25OHD deficiency.Me...

Introduction: Lithium carbonate therapy has continued to be a mainstay treatment for bipolar disease and schizoaffective disorders. Hypercalcemia and hyperparathyroidism (HPT) is an underappreciated, but relatively common occurence, with a prevalence ranging from 6.3 to 50% in patients requiring long-term lithium therapy. It is stil unclear whether lithium initiates HPT or promotes an underlying subclinical state. Lithium antagonizes the calcium-sensing receptor (CASR) resulti...

Background: Laron syndrome (LS) is an autosomal recessive disease characterized by severe postnatal growth failure, short stature, normal or elevated serum GH, and low levels of IGF-I and IGF binding protein-3 (IGFBP-3). The disorder is caused by dysfunction of the growth hormone receptor resulted from mutations in GHR gene.Objective: Purpose of this research was to describe mutations on GHR gene in five children with Laron syndrome.<p class="abstext...

Smoking is a modifyable risk factor in the incidence of impaired glucose tolerance and type 2 diabetes, but the data concerning the effect of smoking on the course of type 2 diabetes is limited. In this study, we aimed to investigate a possible relationship between smoking and the need of insulin therapy in patients with type 2 diabetes. 470 patients with type 2 diabetes were assessed for smoking habitus, marital and educational status, duration of diabetes, duration of insuli...

IntroductionThe diagnosis of insulinomas is made biochemically. However, proper localization of insulinomas is essential before surgery. Non-invasive methods including magnetic resonance imaging (MRI), computed tomography, ultrasonography, glucagon-like peptide-1 receptor PET/CT, 68Ga-DOTATATE PET/CT, and invasive methods such as endoscopic ultrasonography (EUS) and selective arterial calcium stimulation test are used for preoperative localization. Howev...