Searchable abstracts of presentations at key conferences in endocrinology

ea0013p266 | Steroids | SFEBES2007

A case of Addison’s disease associated with hypogonadotrophic hypogonadism

Zachariah Sunil , Hyer Steve

A 30 year old gentleman was admitted to our department with symptoms of tiredness and weight loss over the past 3 weeks. He also gave a history of erectile dysfunction for several years. His only significant past history was asthma well controlled on inhalers. On examination he appeared tanned. There was no buccal or skin crease pigmentation. Smell sensation was normal and he had normal external genitalia and secondary sexual characteristics.Initial inve...

ea0012oc18 | Pituitary, ovary and steroids | SFE2006

Adult onset diabetes insipidus due to congenital midline defects of the brain

Zachariah S , Hyer S

A 30 year old gentleman presented with long standing symptoms of polyuria and polydypsia and poor libido. On examination he was short (155 cm), weighed 108 kg with a body mass index of 45.1. Investigations revealed normal Blood Glucose, renal function, liver function and calcium. Water deprivation test confirmed the diagnosis of Cranial Diabetes Insipidus. He was started on DDAVP tablets 100 microgram’s twice daily. Further tests showed a normal IGF-1, synacthen test and ...

ea0012p74 | Pituitary | SFE2006

Anaemia: A rare presenting feature of pituitary tumour

Zachariah S , Rodin A

A 40 year old gentleman presented to his GP with a 12 month history of tiredness and breathlessness on playing basketball with his son. Initial investigations revealed he had a normocytic anaemia with haemoglobin of 9.8 and white cells and platelets were normal. He was referred to the Gastroenterologists and had normal renal function, liver function, bone profile, ESR and serum electrophoresis. His B12, folate and ferritin were normal. CT Abdomen was normal and duodenal biopsy...

ea0010p5 | Clinical case reports/Governance | SFE2005

Autoimmune Addison’s disease in identical twins

Zachariah S , Russell-Jones D

Autoimmune adrenal insufficiency may be familial or non familial. We report a case of identical female twins, both with Addison’s disease and detectable antibodies to adrenal cortex.Case report: Twin A at age of 27 developed Addison’s disease and hypothyroidism. She was found to be positive for anti-adrenal antibodies, anti-thyroid antibodies and intrinsic factor auto antibodies. Therefore Twin B was tested for the same auto antibodies and was ...

ea0014oc9.6 | Signal transduction | ECE2007

Somatostatin receptor subtype-2 and -3 – selective agonists inhibit insulin secretion from INS-1 cells through modulation of the R-type Ca2+ channel

Mergler Stefan , Singh Vandana , Zacharias Sylvia , Wiedenmann Bertram , Plöckinger Ursula , Strowski Mathias

Objectives: Somatostatin (SST) inhibits insulin secretion from pancreatic B-cells through a reduction of intracellular free calcium ([Ca2+]i). The influx of Ca2+ is mediated by voltage-operated Ca2+ channels (VOCCs). The role of VOCCs of the R-type (CaV2.3) in SST-mediated processes is unknown. Therefore, we designed a study to identify SST-receptor subtypes (SSTR) in insulinoma cells (INS-1) and characterize the role of t...

ea0014p252 | (1) | ECE2007

Somatostatin receptor subtype 2 inhibits glucagon secretion and regulates glucose homeostasis

Strowski Mathias , Singh Vandana , Grötzinger Carsten , Zacharias Sylvia , Wiedenmann Bertram , Plöckinger Ursula

Objectives: Somatostatin (SST) inhibits glucagon and insulin secretion. Five receptor subtypes for SST are known (SSTR1-SSTR5), all of which are expressed in the endocrine pancreas. SSTR2 inhibits glucagon secretion in vitro, however its role in vivo is not well understood. Here, we characterize the role of SSTR2 in regulating glucose homeostasis in mice with diet-induced obesity.Methods: SSTR2-deficient (SSTR2−/−) and control mice...

ea0021p387 | Thyroid | SFEBES2009

Bulbar myopathy as a rare presenting feature of severe thyrotoxicosis in an elderly man

Martin Allison , Foster Kenneth , Zachariah Sunil

A 74-year-old gardener developed progressive dysphagia for solids and liquids over 15 months. He lost five stone in weight and became increasingly weak. There was nothing significant in his past medical and drug histories. He is married, never smoked and drank little alcohol.He had an acute medical admission via A&E in April 2008 for profound dehydration and cachexia. His weight was 41.5 kg. There were no gross neurological deficits but he had hoarse...

ea0015p203 | Neuroendocrinology and behaviour | SFEBES2008

Carcinoid syndrome presenting as chronic diarrhoea in a 88 year old lady with possible primary in the liver

Koshi I , Zachariah S , Schiff R

We present the case of 88 year old lady who presented with long standing history of diarrhoea (18 months). She had been previously investigated under the gastroenterologists with various tests including upper GI endoscopy and colonoscopy. In view of deterioration of symptoms she was admitted under the geriatric team as she could no longer cope with the diarrhoea. On examination she looked well and had fullness in the right hypochondrial region. Blood tests showed abnormal live...

ea0013p281 | Steroids | SFEBES2007

An adrenal ‘coming full circle’

Zachariah Sunil , Nussey Steve , Bano G

37 year old gentleman presented with Cushing’s disease at the age of 15 with obesity, growth retardation, and vertebral fracture. After bilateral adrenalectomy and pituitary irradiation he was treated with hydrocortisone and fludrocortisone. After being lost to follow up for a number of years he was referred to our endocrine clinic in 1999. Clinical examination revealed that he was obese (BMI 39.2), hypertensive and had marked abdominal striae. Investigations revealed an ...

ea0011p220 | Cytokines and growth factors | ECE2006

Effects of IGF-2 on glucose metabolism

Zachariah S , Brackenbridge A , Russell Jones D

The effects of IGF-2 on glucose homeostasis have been more understood from individuals with fasting hypoglycaemia associated with non-islet cell tumours. Endogenous IGFs which circulate in adults fail to exert their immense potential hypoglycaemic activity because they are largely trapped within the vascular space due to their sequestration in a high molecular weight protein complex. The tumours produce excessive amounts of ‘big IGF-2’ which is less readily bound by ...