Endocrine Abstracts

Introduction: Hyperparathyroidism is a condition marked by an overproduction of parathyroid hormone (PTH) due to excessive activity in one or more parathyroid glands. It is a prevalent disorder that may manifest as primary, secondary, or tertiary. In this report, we present three clinical cases highlighting intricate scenarios where determining the primary or tertiary origin of hyperparathyroidism proves challenging.Case reports: A 33-year-old female wit...

Background: Primary hyperparathyroidism (PHPT) is a systemic disease caused by lesions of the parathyroid gland, such as parathyroid adenoma, parathyroid hyperplasia, and parathyroid carcinoma. Bone disease is an important complication of hyperparathyroidism. We herein report a rare case of severe bone disease caused by primary hyperparathyroidism.Case report: A 33-year-old female patient presented with a history of right lower limb pathological fracture...

Introduction: While hypercalcemia is extensively studied in cancer patients, the occurrence of hypocalcemia is not as commonly reported. The unique aspect of this case lies in severe hypocalcemia against the background of a malignant tumor of the cervix, a condition often associated with hypercalcemia.Case report: A 66-year-old patient, diabetic for 13 years with insulin therapy, is being treated for poorly differentiated squamous cell carcinoma of the c...

Introduction: Fournier’s gangrene is a rare and serious poly-microbial necrotizing fasciitis of the perineum and external genitalia, characterized by a fulminant evolution and a high morbidity and mortality. Annual incidence is between 1.6 and 3.3 cases/100,000 patients, with type 2 diabetics accounting for 30% to over 50% of cases, and 66% in women. Observations:Case 1: 48-year-old female, diabetic for 8 years on Metformin, a...

Introduction: According to numerous studies, mesenchymal stem cell therapy is one of the best therapeutic approaches for the treatment of type 1 diabetes. The aim of our study is to provide an update on the contribution of mesenchymal stem cells to glycaemic control and the screening of short-and long-term side effects.Results: We included 5 patients who met our inclusion criteria. The mean age was 21.2 years, with a sex ratio of 0.6. The average duratio...

Introduction: Non-arteritic anterior ischemic optic neuropathy (NOIAN) is acute ischemia of the optic nerve head. It is one of the most common causes of blindness in diabetic patients, especially in the elderly. Visual impairment in NAION may be due to deterioration in visual acuity (VA) and/or visual field (VF) loss. Observation: 51-year-old female patient, diabetic for 14 years on insulin, not well controlled, and hypertensive for 15 years on treatment...

Introduction: Necrotizingfasciitis is a severe infection of deep subcutaneous tissue and hypodermal fascia with secondary skin necrosis.Observation: Patient M.A., aged 67, with no particular pathological history, presented with an 11-day history of a boil on the left forearm, treated with traditional herbs. The evolution was marked by the development of an inflammatory placard on the forearm with extensive necrotic lesions. Ultrasound revealed extensive ...

Introduction: Severe mixed hypertriglyceridemia (SMH) is a highly heterogeneous group of dyslipidemias, both phenotypically and mechanistically (1). The primary origin is dominated by familial combined hyperlipidemia; the most frequent genetic cause. The major concern is the development of acute pancreatitis. We report the case of a patient with mixed hypertriglyceridemia to illustrate the therapeutic difficulties encountered in managing.Clinical case: F...

Introduction: Plasmapheresis is an extracorporeal blood purification method that removes potentially harmful macromolecules (molecular weight L15 - 50 kDa) from the blood. Pancreatitis is a potentially fatal complication of hypertriglyceridemia. The current mainstay of treatment for hypertriglyceridemia associated with pancreatitis includes heparin, insulin and lipid-lowering agents. Experience with plasmapheresis is limited. We report here our experience of using plasmapheres...

Introduction: Endocrine disruptors are natural or chemical molecules capable of interfering with the endocrine system, as well as disrupting the signaling pathways of carbohydrate and lipid metabolism.Materials and methods: This is a retrospective study of 85 patients with a BMI greater than 30 kg/m2 followed in the endocrinology department of CHU Mohamed VI; we studied exposure to endocrine disruptors.Results: 85 patien...