Endocrine Abstracts

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First, it is pertinent to ask WHY we should optimise thyroid status after RAI therapy. The links between poorly controlled thyroid function and patients’ wellbeing, weight and thyroid eye symptoms will be discussed. This talk will also outline the use of block and replace therapy to reduce the risk of thyroid hormone instability following RAI....

Alkaline phosphatase is a widely-ordered test from the clinical laboratory. This brief clinical overview will cover the considerations an endocrinologist should make when assessing a patient referred with an incidental finding of either low or elevated alkaline phosphatase. Some discussion from a laboratory perspective will be included, with a clinic visit and the many caveats for interpretation of alkaline phosphatase in mind, as well as the patient f...

Male Hypogonadism (MH) is a clinical and biochemical diagnosis, comprising pathologically low serum testosterone (T) levels and clinical features of androgen deficiency, of which low muscle mass and increased fat mass are features. The diagnosis is most secure when framed in the context of a recognised clinical syndrome, or with male factor infertility from impaired gonadal function. Testosterone levels in individual males are subject to considerable v...

Pregnancy is associated with changes in both size and function of the pituitary gland. Thus diagnosing pituitary dysfunction during pregnancy can be challenging. For women with a pre-existing adenoma, there is limited evidence regarding safety in pregnancy for medical therapies used to control hormonal excess. Management includes optimisation of hormonal function and close monitoring for signs of tumour progression. Most women can be managed conservati...

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Primary Aldosteronism (PA) is the commonest secondary cause of hypertension. Multiple studies worldwide suggest a prevalence of approximately 10% in an unselected hypertensive cohort and up to 20% in resistant hypertension. This does not correlate with real world experience and PA remains a significantly under-recognised condition. There is a myth that the biochemical diagnosis of PA is complex and requires significant alterations to drug therapy and v...

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