Searchable abstracts of presentations at key conferences in endocrinology

ea0086p238 | Neuroendocrinology and Pituitary | SFEBES2022

Anticoagulation practice for venous thromboembolism prophylaxis in patients with Cushing’s Syndrome - a Society for Endocrinology survey of UK Centres

Isand Kristina , Plummer Zoe E , Volke Vallo , Newell-Price John , Wass John , Pal Aparna

Background: Cushing’s syndrome (CS) is estimated to have a 10-fold increased risk of venous thromboembolism (VTE) compared with the normal population with VTE accounting for 3.6-11% deaths in CS patients. There are no specific guidelines for VTE prophylaxis in CS other than that it should be considered given the increasingly recognised risk.Methods: Via the Society for Endocrinology, we surveyed current VTE anticoagulation practice across UK Endocri...

ea0086p244 | Neuroendocrinology and Pituitary | SFEBES2022

Neuroendocrine tumour (NETs) patient experience of switching to generic somatostatin analogue during the COVID-19 pandemic

Solanke Faith , Elamin Aisha , Newell-Price John , Munir Alia , Ibbotson Victoria

Introduction: In patients with neuroendocrine tumours (NETs) somatostatin analogues are used to control symptoms in patients with functioning tumours and as antiproliferative agents in those with non-functioning tumours. During COVID-19, the ‘Sandostatin Your Choice’ service was terminated by Novartis, removing home care nurses from administering the analogue in patients’ homes. The first generic version of depot octreotide was Olatuton® produced by Teva, a...

ea0090p557 | Adrenal and Cardiovascular Endocrinology | ECE2023

Retrospective study of steroid weaning in tertiary adrenal insufficiency comparing prednisolone and hydrocortisone

Fahad Arshad Muhammad , Elder Charlotte , Newell-Price John , Ross Richard , Debono Miguel

Background: The hypothalamic-pituitary-adrenal (HPA) axis can be suppressed by long-term exogenous glucocorticoids, resulting in tertiary adrenal insufficiency (AI). International expert consensus suggests that during weaning, prednisolone be converted to hydrocortisone to allow HPA axis reactivation(1). There is, however, little evidence to support this practice.Aim: To compare HPA axis recovery during treatment with prednisolone and immediat...

ea0065p270 | Neuroendocrinology | SFEBES2019

Antisense oligonucleotides as a novel medical therapy for Cushing’s disease

Whatmore Jacob , Alzahrani Ahmed , Porter Julie , Kemp Helen , Newell-Price John

Introduction: Cushing’s disease (CD) is a rare but devastating condition, caused by hypersecretion of adrenocorticotropic hormone (ACTH) from a corticotroph adenoma in the anterior pituitary. CD is associated with a five-fold excess mortality and clinical features including hypertension, diabetes mellitus, osteoporosis, and depression. First-line treatment is transsphenoidal surgery, but this is effective in only 65% of cases and the relapse rate is high. Other treatment ...

ea0065p301 | Neuroendocrinology | SFEBES2019

The natural history of pituitary apoplexy: long term follow-up study

Shaikh Ayesha , Shrikrishnapalasuriyar Natasha , Sharaf Giselle , Price David , Udiawar Maneesh , Stephens Jeffrey

Introduction: Pituitary Apoplexy is a rare endocrine emergency which can occur due to infarction or haemorrhage of pituitary gland. Pituitary apoplexy can occur as an initial presentation in patients who are not known to have Pituitary adenomas. Clinical Symptoms vary, however, one should have a high index of suspicion if symptoms such as acute headache, visual loss or ocular palsy occur.Precipitating factors: Hypertension, Preganancy, Head trauma, Dynam...

ea0048cp5 | Poster Presentations | SFEEU2017

Pasireotide: successful treatment of a resistant case of Acromegaly

Liyanarachchi Kamani , Amarawardena Maheshi , Newell-Price John , Ross Richard , Debono Miguel

Case history: A 26 year old lady presented in 1999 with a 3 year history of worsening headache, increased sweating, excessive tiredness and progressive enlargement of hands and feet. She was otherwise well and had no family history of pituitary tumors, hypercalcaemia or renal stones. On examination she had typical facial features of acromegaly and acral enlargement. Her blood pressure was normal and visual fields were full.Investigations: Oral Glucose To...

ea0048wh2 | Workshop H: Miscellaneous endocrine and metabolic disorders | SFEEU2017

An unusual presentation of multiple endocrine neoplasia 1 (MEN1)

Pittaway James , Sahdev Anju , Harrison Barney , Newell-Price John , Drake William

Case history: A 36 year-old man was referred to our department for further evaluation of a large adrenal and multiple liver mass lesions. These had been found on an abdominal ultrasound requested for a 3 week history of mild, episodic abdominal pain. He was asymptomatic but described mild night sweats for over 10 years.Investigations, results and treatment: Hyperparathyroidism was evident, with a serum corrected calcium 3.04 mmol/l (2.15–2.65), PTH ...

ea0046p15 | (1) | UKINETS2016

Low rate of psychological ill health in patients with GEP NETS attending an ENETS Centre of Excellence

Liyanarachchi Kamani , Amarawardena Maheshi , Smith Eleanor , Newell-Price John , Munir Alia

Background: Assessment of psychological burden of disease forms one criterion for accreditation of a cancer specialist center. Patient Health Questionnaire-4 (PHQ-4), a validated self-report ultra-short questionnaire was used to assess anxiety and depression level in patients with GEP NETs, attending the clinics at an ENETS Centre of Excellence.Methods: PHQ-4 was completed during routine outpatient visits over a three month period by 48 patients, who wer...

ea0046p32 | (1) | UKINETS2016

Orbital neuroendocrine tumor metastases: diversity of presentation

Amaraward Maheshi , Liyanarachchi Kamani , Wadsley Jon , Newell-Price John , Munir Alia

Introduction: Orbital metastases from Neuroendocrine tumours (NET) are reported to be very rare, and can be the primary presentation or become evident up to 20 years after diagnosis. We report a series presented in the NET MDT, where ocular metastasis occurred.Case series: A 69-yr-old woman presented with blurred vision, pain and perception of a lump around the left eye. MRI showed a lacrimal gland mass within the orbit. Excision biopsy revealed a TTF1-p...

ea0046p35 | (1) | UKINETS2016

Cardiac metastases from ileal NETs

Liyanarachchi Kamani , Amarawardena Maheshi , Lorenz Eleanor , Newell-Price John , Munir Alia

Background: Intracardiac metastasis of carcinoid tumours are rare (incidence 2–4%). Their presence without carcinoid valvulopathy or carcinoid syndrome is unusual.Case Discussions: A 70 year old male presented with abdominal pain. CT imaging revealed a small intestinal tumor with liver and mesenteric metastasis. Biopsy showed a neuroendocrine tumour (NET). Clinical and biochemical evidence of functionality was absent. He underwent definitive small b...