Searchable abstracts of presentations at key conferences in endocrinology

ea0044ep25 | (1) | SFEBES2016

Association of neurofibromatosis type 1 with primary hyperparathyroidism: report of a case

Austin Emily , Bates Andrew

Introduction: Neurofibromatosis Type 1 (NF1) is an autosomal dominant inherited disorder, which increases the risk of developing both benign and malignant tumours. A Swedish study conducted by Zöller et al in 1997, suggested that up to 25% of these tumours are neuroendocrine in origin, of which phaeochromocytomas were the commonest with a prevalence of 0.1–6%. The association between NF1 and primary hyperparathyroidism is described in the literature but clinically ra...

ea0049ep1259 | Thyroid (non-cancer) | ECE2017

The role of an ultra-sensitive fourth-generation TSH assay in the management of subclinical hyperthyroidism

Austin Emily , Peacey Steve , Bates Andrew

: The management of endogenous subclinical hyperthyroidism is largely guided by perceived risk, including the presence of cardiovascular disease, atrial fibrillation or osteoporosis. We have utilised a fourth-generation TSH assay, providing a 10-fold increase in sensitivity compared to third-generation assays, to determine whether patients with subclinical hyperthyroidism can be differentiated from those with overt hyperthyroidism, based on their now measurable TSH levels. Two...

ea0048cb12 | Additional Cases | SFEEU2017

Investigating menstrual disturbance: a series of unfortunate events

Vamvakopoulos Joannis , Bates Andrew , Rahim Asad

A 20-year-old lady presented to her GP with menstrual irregularity and worsening right-sided headaches with associated vomiting. Blood tests showed a mildly raised testosterone level and a markedly raised prolactin level, approximately 80% of which was macroprolactin (normal monomeric prolactin level). She was subsequently referred by her GP for an MRI Pituitary, which was reported as showing a 6-mm hypoenhancing lesion. Medical history includes migraines and hayfever; she was...

ea0019p27 | Clinical practice/governance and case reports | SFEBES2009

The utility of routine biochemistry in detecting vitamin D deficiency in South Asians with and without type 2 diabetes

Tahrani A , Ball A , Shepherd L , Rahim A , Bates A

Background: Vitamin-D deficiency and type 2 diabetes (T2D) are common in South Asians (SA). The diagnosis of a vitamin-D deficiency in the setting of a chronic disease depends on a high index of suspicion and adequate investigation. This involves bone profile, occasionally in conjunction with serum 25-hydroxyvitamin-D. The ability of routine investigations to identify vitamin-D deficient patients have not been widely studied.Aims: To assess the ability o...

ea0013p187 | Diabetes, metabolism and cardiovascular | SFEBES2007

The prevalence and detection of vitamin d insufficiency in Asian patients with type 2 diabetes

Yemparala Meher Prasad , Shepherd Lisa , Rahim A , Bates AS

Aim: To determine the prevalence of vitamin D insufficiency in Asian patients with type 2 diabetes and to determine the most appropriate screening investigations.Introduction: The high prevalence of vitamin D deficiency and type 2 diabetes in the Asian community is well recognised. Vitamin D insufficiency (levels < 50 nmol/l) is associated with impaired insulin secretion and increased insulin resistance. The prevalence of Vitamin D insufficiency in p...

ea0007p125 | Endocrine tumours and neoplasia | BES2004

The changing patterns of presentation and treatment of acromegaly in the UK as reflected by the UK National Acromegaly Database

Wass J , Carson M , Bates P

The UK Acromegaly Register was established in 1997 and holds data on patients with acromegaly from 17 centres in the UK. Of 1466 records, 431 (29%) were diagnosed pre-1984, 580 (40%) between 1984 and 1993 and 455 (31%) between 1994 and 2003.Surgery was and remains the most frequently applied primary treatment for acromegaly: 46% of cases pre-1984, 53% 1994-2003. The proportion treated by surgery alone has risen from 16% to 28% in 1994 to 2003 (P<1x10-...

ea0077p175 | Metabolism, Obesity and Diabetes | SFEBES2021

Pressure from pericytes: angiotensin II induced neuropathic pain development as a complication of hypertension

Hardowar Lydia , Sheavyn Matt , McTernan Philip , Bates Dave , Hulse Richard

The renin angiotensin system (RAS) is targeted as means of medical intervention for hypertensive associated complications of stroke, heart failure and obesity. Ultimately, the inhibition of Angiotensin II(ANGII)/Angiotensin II type 1 (AT1) receptor complex has been key in reducing raised blood pressure. Diabetic neuropathic pain (NP) is highly prevalent in the United Kingdom, associated with an increasingly aged population. There is growing acknowledgment that the vascular com...

ea0041gp3 | Adrenal | ECE2016

Follow-up of adrenal incidentalomas – are we overdoing it? Follow-up of 145 patients from a single centre

Austin Emily , Miller Ben , Shepherd Lisa , Bates Andrew

Background: Current practice of monitoring adrenal incidentalomas with biochemical follow-up and repeat imaging studies is under review by the ESE.Following an audit presented in 2015, we proposed that this extensive follow-up was unnecessary in radiologically benign lesions, as neither functional nor malignant lesions were present in this subgroup.Methods: A retrospective review of the same cohort of 145 patients with adrenal inci...

ea0038p49 | Clinical practice/governance and case reports | SFEBES2015

Outcome of patients with adrenal incidentalomas: an analysis of 145 patients from a single centre

Austin Emily , Rahim Asad , Shepherd Lisa , Bates Andrew

Adrenal incidentalomas are a common clinical dilemma with increasing utilisation of cross-sectional imaging modalities. The aims of management include: i) exclusion of possible malignancy and ii) identification of hormonally active lesions.Our unit has adopted AACE guidelines, including a screen for adrenal androgen hypersecretion. This audit aimed to review the utility of such an approach.We identified case notes of 145 consecutiv...

ea0038p68 | Clinical practice/governance and case reports | SFEBES2015

Management of thyroid disease in pregnancy: experience from an antenatal thyroid clinic

Thomas Micha , Hassan-Smith Zaki , Bates Andrew , Rahim Asad

Background: Thyroid disease in pregnancy is common with hypothyroidism predominating.Objectives: To determine the aetiology of thyroid disease in patients attending an antenatal thyroid clinic, their baseline biochemical and therapeutic characteristics as well as subsequent management.Subjects/setting: 114 women with a mean 31 years (±5) age were seen by a consultant endocrinologist in the antenatal thyroid clinic, between Sep...