Searchable abstracts of presentations at key conferences in endocrinology

ea0034pl5 | SfE Transatlantic Medal Lecture | SFEBES2014

Transcriptional coordination of circadian and metabolic physiology

Lazar Mitchell

Organismal metabolic homeostasis is normally accomplished by the physiological functions of several metabolic tissues, including liver, muscle, and fat. The endocrine system coordinates organismal metabolic homeostasis via hormones, such as insulin and glucocorticoids, that act on metabolic tissues to partition nutrients within a physiological range. Metabolic diseases, such as obesity and diabetes, ensue when these homeostatic systems fail. Normal metabolic physiology also di...

ea0034pl5biog | SfE Transatlantic Medal Lecture | SFEBES2014

SfE Transatlantic Medal Lecture

Lazar Mitchell A

Mitchell A LazarDr Mitchell Lazar is the Sylvan Eisman Professor of Medicine and Genetics, the Chief of the Division of Endocrinology, Diabetes, and Metabolism, and the Director of the Institute for Diabetes, Obesity, and Metabolism at the University of Pennsylvania. He received his undergraduate degree in Chemistry from the Massachusetts Institute of Technology, then received a PhD in Neurosciences and an MD from Stanford University. He trained in Inter...

ea0029p1801 | Thyroid cancer | ICEECE2012

Role of realtime elastography in diagnostic of thyroid cancer

Stoian D. , Cornianu M. , Lazar F.

Background: The most important aspect in the diagnostic approach of thyroid nodule is identifying the malignancy. Elastography is a newly technique that measures the elasticity of tissue, after applying a external force, standardized control. US elastography is currently used in differentiation of malignant from benign lesions.Material, Method: This prospective study included 69 patients, mean age 50.08±12.43 years, 67 females and 2 men, with thyroi...

ea0029p1840 | Thyroid cancer | ICEECE2012

Diagnostic power of conventional and doppler ultrasound in identifying malignancy in thyroid nodules

Stoian D. , Cornianu M. , Lazar F.

Background: Conventional ultrasound remains the most used imaging evaluation in case of a thyroid nodule.Material, method: This prospective study included 69 patients (107 nodules). Conventional and Doppler ultrasound was performed with a HITACHI EUB 7500 HV machine with 6–13 MHz variable frequency linear probe, with Doppler software. All patients underwent surgery after complete evaluation.Postsurgical histopathological exam was performed. We analy...

ea0063p872 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Adrenocortical cancer: our experience in a tertiary center of endocrinology

Lazar Elena , Caragheorgheopol Andra , Tomulescu Victor , Badiu Corin

Adrenocortical cancer is a rare, aggressive disease, requiring a fast and multidisciplinary approach. The genetics is heterogeneous so is also the clinical course. In the last 10 years, we have diagnosed and treated a number of 20 cases, aged at diagnosis between (34–74 years) (mean 55.9±12.87), followed up between (2–77 months) (mean 25.75±23.58). The maximal diameter of the tumor was (5.5–25) (mean 10.95±5.43). The secretion profile was Cushing ...

ea0041ep256 | Clinical case reports - Pituitary/Adrenal | ECE2016

Atypical X-linked adult adrenoleukodystrophy with cerebellar and brainstem involvement – a case report

Lazar Elena , Ilie Mirela , Tanasescu Radu , Popescu Bogdan , Badiu Corin

Background: X-linked adrenoleukodystrophy (ALD) is a peroxisomal disorder of beta-oxidation that results in accumulation of very long chain fatty acids (VLCFAs) in various tissues. The clinical phenotype of X-ALD in adults is variable and involves adrenal, gonadal and nervous system dysfunction (adrenomyeloneuropathy, AMN). Patients with AMN typically develop spastic paraparesis due to progressive degeneration of the cerebral white matter.Objective: To r...

ea0035p550 | Endocrine tumours and neoplasia | ECE2014

The effectiveness of yttrium90/lutetium177-labeled somatostatin analogues treatment in functional pNETs

Michalik Barbara , Handkiewicz-Junak Daria , Hasse-Lazar Kornelia , Jarzab Barbara

Introduction: Therapy with somatostatin analouges is usually ineffective to remove hormonal symptoms in patients with functional pancreatic neuroendocrine tumors (pNET). Alternative treatment modalities, to control symptoms of excessive hormonal production, are necessary. Thus, the aim of our study was to evaluate results of radiopeptide treatment in patient with functional pNET.Materials and methods: 92 patients with pNET (49 women and 43 men, median ag...

ea0011p401 | Diabetes, metabolism and cardiovascular | ECE2006

The effect of hyperthyroidia on glycemic control in patients with diabetes mellitus

Fica S , Barbu C , Lazar A , Grigorescu M , Albu A , Bunghez R

The aim of the study was to evaluate the effects of hyperthyroidia on glycemic control in patients with diabetes mellitus.Research design and methods: We retrospectively evaluated the patients with diabetes and hyperthyroidism. We analysed clinical data, thyroid ultrasound exploration, laboratory analyses (glycosylated hemoglobin, free thyroxin FT4, triiodothyronine T3, thyroid stimulating hormone TSH).Results: We evaluated 48 pati...

ea0056p718 | Clinical case reports - Pituitary/Adrenal | ECE2018

Post-traumatic hypopituitarism – a case report

Lazar Elena , Marin Alexandra , Dobrescu Ruxandra , Badiu Corin

Background: Head trauma of sufficient severity, particularly causing fracture to the skull base, can cause deficient secretion of anterior pituitary hormones and vasopressin. Severe hypopituitarism and diabetes insipidus (DI) are common post-traumatic events but they can recover 3 and 12 months afterwards.Objective: To report a case of a woman with post-traumatic hypopituitarism and DI after car accident.Case report: A 31 year old ...

ea0086p93 | Neuroendocrinology and Pituitary | SFEBES2022

Circadian/diurnal rhythm profiles of serum and salivary melatonin, cortisol and cortisone, determined by liquid chromatography tandem mass spectrometry (LC-MS/MS)

Webb Bethany , Dunn Rachel , Ball Nicole , Fraser William , Lazar Alpar , Michalak Adriana , Voysey Zanna , Tang Jonathan

Background: Melatonin and cortisol production demonstrate circadian rhythms; disruption of these rhythms feature in endocrine and neurodegenerative disorders, such as Addison’s disease, Huntington’s disease (HD) and Alzheimer’s disease (AD). Measuring serum and saliva concentrations at nadir is challenging using immunoassays. We have developed LC-MSMS methods for measuring serum and saliva melatonin, cortisol and cortisone to analyse 24hr profile samples obtained from sleep st...