Endocrine Abstracts

Background: Glycemia point-of-care testing (POCT) is performed with fingerstick capillary whole-blood glucose measurement. These values correlate well with plasma glucose values. Hypoglycemia can be observed with POCT but should always be confirmed on plasma. True hypoglycemia must meet Whipple’s triad: signs/symptoms of hypoglycemia; low plasma glucose; improvement after glucose administration. Artifactual hypoglycemia is a discrepancy between POCT and plasma glucose and...

Introduction: First assessment of lung tumors is often performed by imaging combined with biopsy. This is necessary for immunohistochemical tumor typing, evaluation of treatment options and prognosis. It has been shown in literature reviews that Endobronchial ultrasound (EBUS) with fine needle aspiration cytology (FNAC) is not inferior in diagnostic quality, but much less invasive than mediastinoscopy of chest laparotomy (1–3). In this case report we will describe the cut...

Background: Glycaemia point-of-care testing (POCT) is performed with fingerstick capillary whole-blood glucose measurement. These values normally correlate well with plasma glucose values. Hypoglycemia can be observed with POCT but should always be confirmed on plasma. True hypoglycemia must meet Whipple’s triad: signs/symptoms of hypoglycemia; low plasma glucose; improvement after glucose administration. Artifactual hypoglycemia is defined as a discrepancy between POCT a...

We describe the case of a 60-year old woman admitted to the intensive care unit (ICU) for progressively diminishing consciousness and severe lethargy. The patient was recently diagnosed with small cell lung carcinoma with solitary cerebral metastasis. In order to shrink the metastasis-induced cerebral edema she was treated with dexamethasone. She was hospitalized four days before admission to the ICU to start carboplatin-etoposide based chemotherapy. The day of admission she h...

Genome sequence projects in combination with advances in mass spectrometry and bioinformatics have created several new possibilities for comparative endocrinology. In 2001 we introduced the peptidomics technology that allows the identification of the complement of native (neuro)peptides in cells, tissues, organs and organisms. Especially when genome sequence information is available (D. melanogaster, A. mellifera, C. elegans…), neuropeptidomes were successfully id...

Background and AimsPeople with type 1 diabetes (T1D) have an increased risk of cardiovascular disease (CVD) despite insulin therapy to treat hyperglycaemia. Insulin resistance may be a contributing factor to CVD. Insulin resistance is strongly associated with NAFLD, which is increasingly linked to CVD. The estimated glucose disposal rate (eGDR) correlates well with the euglycemic clamp, which is the gold standard to assess insulin resistance in T1D, but ...

Background and aims: Insulin resistance is increasingly prevalent in patients with type 1 diabetes (T1D). Insulin resistance is associated with both cardiovascular complications and non-alcoholic fatty liver disease (NAFLD), but its assessment is challenging in T1D due to the technical difficulties of the euglycaemic clamp technique. The estimated glucose disposal rate (eGDR) is a validated alternative to quantify insulin resistance in T1D, but its role in clinical practice is...

Introduction: The prevalence of metabolic syndrome is increasing in individuals with T1D, which could potentiate the development of NAFLD. The pathophysiology of NAFLD in T1D is still unclear, due to the co-existence of predisposing and protective factors. Insulin resistance (IR) is theorized as a key driver of NAFLD.Aim: We investigated the association between liver fat content (LFC), NAFLD, and IR in individuals with T1D. Subjects underwent magnetic re...

Background: Insulin resistance is proposed as a causative factor of non-alcoholic fatty liver disease (NAFLD) in the general population. Reports on NAFLD in type 1 diabetes (T1D) are increasing , but whether insulin resistance is linked to NAFLD in this population needs elucidation. Furthermore, people with T1D are an excellent model to investigate insulin resistance in relation to NAFLD without confounding by autologous insulin production.Aims and Metho...

Introduction: Nonalcoholic fatty liver disease (NAFLD) affects ±55% of subjects with type 2 diabetes and contributes to cardiovascular mortality. NAFLD data in type 1 diabetes (T1DM) are scarce. Biopsy is the diagnostic reference but is not suited for routine screening. Ultrasound (US) is validated to diagnose steatosis as first-line imaging but is restricted to trained operators. The Fatty Liver Index (FLI) is a score to predict fatty liver based on triglycerides, Body M...