Endocrine Abstracts

The treatment of papillary thyroid cancer consist of surgery and if indicated post-surgical administration of radioiodine with the initiation of thyroid hormone substitution. Whether or not a patient receives a post-operative radioiodine treatment largely depends on the pathological staging (TNM).Through observational data, the benefit of additional radioiodine treatment was only significant in patients with thyroid cancer classified as high risk accordi...

Context: A lingual thyroid is a relatively rare clinical entity. It is the most common subtype of ectopic thyroid. An ectopic thyroid is caused by an aberrant descent of the thyroid gland from the foramen caecum to its normal pretracheal position during embryogenesis. A lingual thyroid is located at the midline of the tongue base. It can be asymptomatic, but it may also cause dysphagia, upper airway obstruction, haemorrhage or dysphonia. Moreover, about 70% of patients with li...

Background: Thyroid cancer incidence is increasing, especially the cancers ≤1 cm (T1a). Previous evidence suggests underuse of FNA. Several international guidelines for the management of thyroid cancer have been published. Especially the year 2006 was a hallmark, with the publication of both the ETA consensus and ATA guidelines.Aim: Compare thyroid cancer subtypes and management before and after 2006.Methodology: Retrospectiv...

Background: 1,25-dihydroxy vitamin D mediated hypercalcemia resulting from an inflammatory reaction caused by a foreign body such as a textiloma has never been described.Clinical case: A 61 year-old man with a medical history of Alport syndrome and in need of chronic dialysis after transplant kidney resection because of relapsing severe urinary tract infections, presented with recurrent and progressive hypercalcemia two years after parathyroidectomy (C a...

Introduction: (Anti-TNF-α) therapy is widely used for the treatment of inflammatory diseases. The most frequent adverse events induced by anti-TNF-α therapy are infections and malignancies. However, reports of paradoxical sarcoidosis-like reactions are on the rise in patients receiving anti-TNF-α.Clinical case: A 61-year old woman, with a medical history of sero-positive rheumatoid arthritis on Adalimumab treatment (anti-TNF-α), was r...

Introduction: Neurofibromatosis type 1 (NF1) is an autosomal dominant neurocutaneous disorder characterised by the appearance of multiple, mostly benign, tumours throughout the skin and central nervous system. Furthermore, NF1 is associated with a number of (pre)malignant tumours including pheochromocytoma, glioma, invasive breast cancer and (pre)malignant peripheral nerve sheath tumours (1). Approximately 1:2500 to 1:3500 individuals are affected.Medull...

Case: An eighteen-year-old male was forwarded to our department by the ophthalmologist because of the resection of an angiomyxoma of the right eyelid. Medical history included multiple surgically excisions of myxomatous tumors from the skin (gluteal, scapular…). Clinical examination showed some lentiginous lesions on his back and more important clear stigmata of acromegaly (tall stature, wide nose, large hands…). Hence our suspicion of a syndromic disorder, in part...

Background: Thyroid incidentaloma are asymptomatic thyroid nodules that are discovered on an imaging study performed to evaluate other structures. Clinically unrecognized thyroid nodules are common and can be found in up to 50–60% of patients at autopsy.1 Increased use of imaging modalities of better quality in the modern era has resulted in an increased detection of incidental thyroid nodules. The prevalence rate is 67% with ultrasonography (US) imaging, 15% w...

Background and objective: Increased prescription of levothyroxine (LT4) has been observed in the USA and countries in Europe and has been related to increased thyroid function screening and a lower treatment threshold, increasing risk for overdiagnosis and overtreatment. We wanted to study the evolution of LT4 prescriptions in Belgium, and compare the use of anti-arrhythmic drugs (AAD) and bone-anti-resorptive drugs (BAD) between LT4-users and non-LT4-users.<p class="abste...

Introduction: Several studies identified pre-treatment parameters that could help in the prediction of the thyroid functional outcome after radioactive iodine therapy (RAI) in Graves’ disease. However, the role of the thyroid peroxidase antibody (TPO Ab) status is not well studied.Objectives: We investigated if a positive TPO Ab status before radioactive iodine (RAI) therapy in patients with Graves’ hyperthyroidism is a predictive factor for de...