Endocrine Abstracts

Introduction: Glucose-induced osmotic diuresis and free water loss induced by the SGLT2 inhibitor empagliflozin effectively increase sodium levels in patients with a chronic syndrome of inappropriate antidiuresis (SIAD) where arginine vasopressin (AVP) levels are inappropriately increased in relation to osmolality. The hormone apelin opposes the actions of AVP in salt and water homeostasis and administering exogenous apelin increases sodium levels in rats with SIAD. In patient...

Introduction: In polyuria-polydipsia syndrome (PPS) the differentiation between arginine vasopressin deficiency (AVP-D) and primary polydipsia (PP) remains challenging and a stimulation test is required. Apelin is an endogenous hormone that antagonises AVP and seems to play an important role in regulating salt and water homeostasis. The dynamic of apelin plasma levels in patients with PPS undergoing copeptin stimulation tests is unknown.Methods: Post-hoc...