Searchable abstracts of presentations at key conferences in endocrinology

ea0020p465 | Obesity and Metabolism | ECE2009

Glucose-dependent insulinotropic polypeptide modulates inflammatory markers in adipose tissue

Gogebakan Ozlem , Osterhoff Martin , Mosig Sandy , Middelbeck Ines , Rudovich Natalia , Schuler Rita , Pfeiffer AFH

Background: Glucose-dependent insulinotropic polypeptide (GIP) is a gastrointestinal hormone that is secreted in response to food intake. GIP acts on various tissues, including pancreatic ß-cells, via interaction with its G-protein-coupled receptor. Some studies in rodents suggested that GIP directly links overnutrition to obesity. GIP exerts a physiological role on lipid uptake into adipocytes.Objectives: To analyse the effect of GIP-Infusions on c...

ea0016p215 | Diabetes and cardiovascular diseases | ECE2008

Metabolic changes induced by glucose infusion in persons with Glu23Lys polymorphism

Bobbert Thomas , Mittag Marc , Mai Knut , Fischer Antje , Arafat Ayman , Pfeiffer AFH , Spranger Joachim

The development of diabetes mellitus type 2 (T2DM) is affected by genetic and lifestyle factors. Polymorphisms within the KIR6.2 gene seem to be associated with a higher risk for T2DM. The protein encoded by this gene represents a potassium channel, which plays an essential role in insulin and glucagon secretion by the pancreas.A hyperglycaemic clamp without insulin was performed over 2 h in 10 healthy persons with the Kir6.2 E23K wild type Glu/Glu, 10 a...

ea0011p405 | Diabetes, metabolism and cardiovascular | ECE2006

Growth hormone and IGFBP-3 but not IGF-1 are independent predictors for insulin sensitivity in healthy subjects: on the role of hGH in the metabolic syndrome

Arafat MA , Perschel F , Schöfl C , Weickert M , Purschwitz J , Rochlitz H , Spranger J , Möhlig M , Pfeiffer AFH

Objectives: Insulin resistance (IR) and obesity are very common metabolic abnormalities, which are often associated with reduced GH secretion. GH reduces intraabdominal fat and its deficiency may contribute to the metabolic syndrome. IGF-1 improves IR but IGFBPs have a potential role in regulating its bioactivity although only little information exists. We postulate that the elevated insulin levels in IR may persistently suppress GH provided its regulation remains insulin sens...

ea0011p642 | Neuroendocrinology and behaviour | ECE2006

Glucagon-induced suppression of ghrelin secretion is exerted at hypothalamus-pituitary level and is not mediated by an increase in catecholamine secretion

Arafat MA , Perschel F , Otto B , Weickert M , Rochlitz H , Schöfl C , Spranger J , Möhlig M , Pfeiffer AFH

Objective: The mechanisms underlying the well known glucagon-induced satiety effect are unclear. We showed earlier that glucagon induces a remarkable decrease in the orexigenic hormone: ghrelin. It was the aim of the present study to further evaluate the effect of glucagon on ghrelin secretion and the possible site of origin of this effect.Methods: We studied the endocrine and metabolic responses to intramuscular glucagon administration in 23 subjects (1...