Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep604 | Pituitary and Neuroendocrinology | ECE2020

Salivary cortisol and cortisone – Effects of liquorice and blood contamination

Bäcklund Nils , Imamovic Marcus , Brattsand Göran , Lundstedt Staffan , Aardal Elisabeth , Olsson Tommy , Dahlqvist Per

Context: Late-night salivary cortisol is a recommended screening method for Cushing’s syndrome. Liquorice intake may lead to falsely elevated salivary cortisol as glycyrrhizic acid inhibits the 11β-hydroxysteroid dehydrogenase type 2 induced conversion of cortisol to cortisone in the salivary glands. Furthermore, sample contamination by blood from the oral mucosa may also cause falsely elevated salivary cortisol levels. Salivary cortisone has been suggested to more ...

ea0081p10 | Adrenal and Cardiovascular Endocrinology | ECE2022

Comparison of assays for salivary cortisol and cortisone in the diagnosis of Cushing’s syndrome

Backlund Nils , Brattsand Goran , Lundstedt Staffan , Aardal Elisabeth , Bartuseviciene Inga , Katarina Berinder , Burman Pia , Eden Engstrom Britt , Hoybye Charlotte , Isaksson Anders , Ragnarsson Oskar , Ruetschi Ulrika , Wahlberg Jeanette , Olsson Tommy , Dahlqvist Per

Background & Objective: Late night salivary cortisol (LNSC) and 1 mg overnight dexamethasone suppression test (DST) are two of the three recommended screening tests for Cushing’s syndrome (CS). The classical DST uses serum cortisol, but analysis of salivary cortisol and cortisone has shown high diagnostic accuracy at DST (1). Salivary cortisol can be analysed with immunoassays, which suffer from variable degree of cross reactivity with other steroids, or with LC-MS/MS...