ea0086p211 | Metabolism, Obesity and Diabetes | SFEBES2022
Parenti Cristina
, Murphy Alice M.
, Lad Nikita
, McTernan Philip G.
, Nelson Carl P.
, Sharpe Graham R.
, Barber Claire
, Abadalkareem Rana
, Azim Adnan
, Kurukulaaratchy Ramesh J.
, Haitchi Hans M.
, Williams Neil C.
Background: Obesity exacerbates a number of chronic inflammatory diseases including asthma, with increasing adiposity observed to worsen asthma severity and disease control. This exacerbation may arise as gut-derived bacterial fragments (endotoxin) and associated markers of endotoxin (lipopolysaccharide binding protein (LPB)), enter the circulation through a damaged gut barrier, provoking systemic inflammation. This study investigated the role of body weight on gut permeabilit...