Endocrine Abstracts

Background: Patients with hypoparathyroidism require frequent calcium measurements and currently there is no point of care device allowing this to be done at home by patients themselves. The aim of our study was to evaluate whether ionized calcium(iCa) can be accurately measured in venous and capillary blood and saliva by a repurposed device LAQUA.(R&D Ref 18/0058– IRAS 236079)Methods: Patients undergoing thyroid and parathyroid surgery underwen...

Introduction: Histology is a poor predictor of the malignant potential of phaeochromocytomas and paragangliomas (PPGL) and only the presence of distant metastasis confirms malignancy. This study reviews patterns of recurrence, treatment and mortality in patients with malignant PPGL presenting to our department at UCLH over 30 years.Materials and Methods: In our series of 128 patients with PPGL, 26 (20%) with maligna...

Introduction: Histology is a poor predictor of the malignant potential of phaeochromocytomas and paragangliomas (PPGL) and only the presence of distant metastasis confirms malignancy. This study reviews patterns of recurrence, treatment and mortality in patients with malignant PPGL presenting to our department at UCLH over 30 years.Materials and Methods: In our series of 128 patients with PPGL, 26 (20%) with maligna...

Introduction: Primary hyperparathyroidism is a common endocrine disorder, surgery is curative. Patients with severe hypercalcemia receive cinacalcet or intravenous bisphosphonates as bridging. Intra-operative-parathyroid-hormone (IOPTH) measurement improves surgical accuracy. Bisphosphonates may increase PTH, while cinacalcet reduces it. The main aim was to assess the effect of zoledronate and cinacalcet on IOPTH.Method: Patients over 15-yo who underwent...

Background: Characterisation of large adrenal lesion is challenging. There is no single robust imaging marker in defining benignity, especially for lesions which are greater than 4cm and are believed to carry increased risk of malignancy.A radiolabelled cholesterol analog tracer, I-131-Norcholesterol (NP-59), localises to adrenal cortical lesions. It has an established role in Conn’s syndrome. It is not expected to concent...

Background: Characterisation of large adrenal lesion is challenging. There is no single robust imaging marker in defining benignity, especially for lesions which are greater than 4cm and are believed to carry increased risk of malignancy.A radiolabelled cholesterol analog tracer, I-131-Norcholesterol (NP-59), localises to adrenal cortical lesions. It has an established role in Conn’s syndrome. It is not expected to concent...

Background: Patients with Multiple Endocrine Neoplasia type 2 (MEN2) without previous family history often present late with advanced Medullary Thyroid Cancer (MTC). Surgery is not always curative but RET tyrosine kinase pathway is a potential target for molecular treatment for progressive MTC.Methods: Retrospective review of clinical, genetic, biochemical (calcitonin, CEA) and imaging (US, CT/MRI, Gallium Dotate) data of children with MEN2 who developed...

Introduction: Sphingosine-1-phosphate lyase (SGPL1) catalyses the final step in sphingolipid metabolism, irreversibly degrading the lipid signalling molecule sphingosine-1-phosphate (S1P). The relative abundance of S1P compared to its precursors sphingosine and ceramide finely tunes signal transduction for a wide range of cellular pathways including proliferation, apoptosis, migration and calcium handling. Loss-of-function mutations in SGPL1 cause a spectrum of disorders, incl...