Endocrine Abstracts

Background: Care of patients with diabetes should include an assessment of bone health. It is now clear that patients with type I DM have lower bone mineral density which may be manifested as osteopenia in growing skeleton and higher risk of fractures.Objective: To assess bone modelling through the measurement of bone formation and resorption indexes in diabetic children and their correlations with metabolic parameters.Methods: We ...

Acute lymphoblastic leukaemia (ALL) is the most common childhood cancer. Given dramatic improvements in survival rate (>80%), long term quality of life is of rising concern. Skeletal complications including osteonecrosis (ON) are being reported more frequently, affecting up to 38% of children treated for ALL though the pathogenesis is unclear.The purpose of this study is to examine possible mechanisms causing ON. We hypothesize that polychemotherapy ...