Endocrine Abstracts

Hypercalcemia is a rare pathology in pregnancy and postpartum, but an important one to recognize in the effort to reduce fetal and neonatal morbidity and mortality. We describe a case of hypercalcemia at end of pregnancy. A30 year-old woman was referred to Endocrine clinic at 36 weeks Gestations for symptomatic mild hypercalcemia (tired and lack of energy). She had previous history of acute lymphocytic leukemia treated with bone Marrow Transplant in remission for the last 6 ye...

Hyponatraemia is the most commonly recorded electrolyte abnormality occurring in 7% to 8% of elderly, ambulatory patients and 15 to 20% of hospitalized patients presenting a variety of symptoms ranging from very mild to life threatening. Correction of hyponatremia has been shown to improve the symptoms and signs associated with this condition. It is also recognized that excessively rapid correction of hyponatremia can be detrimental. During hospital admission, hyponatremia is ...

New immune-modulatory therapies for malignancies have transformed their management with significantly enhanced survival outcomes. Pembrolizumab is an antibody against the programmed-death-1 molecule that increases the cytotoxic function of T-cells with excellent tumor response rates. Endocrinopathies including thyroiditis are an increasingly recognized side effect of this medication. We describe a unique a case where Thyroiditis occurred as a result of treatment with Pembroliz...

Thyroid-associated ophthalmopathy (TAO) is an inflammation of the extraocular muscles and periorbital connective tissue caused by autoantibodies against common antigens to both the thyroid and orbit. The release of antigens and induction of hypothyroidism caused by radioactive iodine (RAI) therapy may cause or exacerbate TAO. Radioactive iodine therapy has been associated with worsening TAO, particularly in smokers. A 57 years old female treated with radioactive iodine therapy...

Pituitary hyperplasia is a relatively common condition that occurs in both physiological and pathological states. Pregnancy is the most common condition associated with physiological pituitary enlargement, associated primarily with lactotroph hyperplasia. Pathological hyperplasia has been shown to be associated with end organ insufficiency from primary gonadal insufficiency, primary adrenal insufficiency, and primary hypothyroidism. We present the case of a 33-year-old male wi...

Reactive hypoglycaemia after gastric bypass surgery is characterized primarily by excessive postprandial hyperinsulinaemia and resultant neuroglycopaenic symptoms. The elusive pathophysiology of this problem has made treatment challenging. We describe the first case report where treatment with the Sodium Glucose Transporter Inhibitor canagliflozin has reduced hypoglycaemic episodes after failure of other therapies.A 56 year o...

We report a rare case of hyperthyroidism secondary to Graves’ disease which failed to respond to three consecutive therapeutic doses of radioactive iodine 131.This 62 year old gentleman with a history of ischaemic heart disease was first referred to endocrine services in September 2014 with classical symptomatic hyperthyroidism. He described fatigue, significant weight loss of 3.5 stones, sweating, palpitations and heat intolerance ove...

Radioactive iodine is used routinely and safely in the treatment of hyperthyroidism. We describe an unusual side effect after a single treatment in a patient with subclinical hyperthyroidism.A 64 year old woman was referred to our service with multinodular goitre. She was found to have subclinical hyperthyroidism with TSH 0.17 mU/L, fT3 5 pmol/L and fT4 14 pmol/L. She underwent radioactive iodine treatment with 530 MBq of Iodine -131 in Jan...

Reactive hypoglycaemia after gastric bypass surgery is characterized primarily by excessive postprandial hyperinsulinaemia and resultant neuroglycopaenic symptoms. The elusive pathophysiology of this problem has made treatment challenging. We describe the first case report where treatment with the Sodium Glucose Transporter Inhibitor canagliflozin has reduced hypoglycaemic episodes after failure of other therapies.A 56 year o...

We report a rare case of hyperthyroidism secondary to Graves’ disease which failed to respond to three consecutive therapeutic doses of radioactive iodine 131.This 62 year old gentleman with a history of ischaemic heart disease was first referred to endocrine services in September 2014 with classical symptomatic hyperthyroidism. He described fatigue, significant weight loss of 3.5 stones, sweating, palpitations and heat intolerance ove...