Searchable abstracts of presentations at key conferences in endocrinology

ea0044p127 | Neoplasia, cancer and late effects | SFEBES2016

A review of the diagnostic sensitivity of plasma metanephrine testing in patients with SDH gene mutations

Abraham Shalin , Casey Ruth , Pitfield Deborah , Challis Ben , Simpson Helen

Phaeochromocytomas (PC) are tumours of the adrenal medulla and paragangliomas (PGL) refer to their extra-adrenal counterpart arising from sympathetic or parasympathetic tissue. Mutations in the citric acid cycle enzyme succinate dehydrogenase (SDH) predispose to PC/PGL. Clinical practice guidelines suggest that plasma metanephrine and normetanephrine levels measured in the supine position should be used in the first instance for biochemical diagnosis, and those with positive r...