Searchable abstracts of presentations at key conferences in endocrinology

ea0081rc1.6 | Rapid Communications 1: Diabetes, Obesity, Metabolism and Nutrition 1 | ECE2022

Evidence for three superimposed components, via which metformin affects blood glucose in obese mice

Kaplanian Mairam , Philippe Cecile , Beghini Marianna , Metz Matthaeus , Abu Eid Sameer , Kautzky-Willer Alexandra , Scherer Thomas , Furnsinn Clemens

Introduction: Despite a plethora of suggested targets and pathways, the mechanism of anti-hyperglycaemic metformin action is still unknown. The present study critically re-analysed protocols broadly applied in preclinical rodent studies.Methods: Obese male C57BL/6J mice on high fat diet were treated with metformin in the form of a single dose, daily intraperitoneal injections, admixture to drinking water, or continuous infusion via intraperitoneal minipu...

ea0081p96 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Increased haematocrit mediates lowering of blood glucose in mice exposed to hypoxia or treated with erythropoetin

Scherer Thomas , Metz Matthaeus , Beghini Marianna , Durr Sabine , Corina Luca Andreea , Kaplanian Mairam , Abu Eid Sameer , Kautzky-Willer Alexandra , Furnsinn Clemens

Introduction: Mountain dwellers show a lower prevalence of diabetes, which among countless other factors could be due to lower partial oxygen pressure at high altitude. The present study was to investigate in an experimental setting, if and how reduced oxygen availability affects blood glucose.Methods: Male obese mice on high fat diet were continuously maintained under a normobaric hypoxic atmosphere (10% oxygen) for three months. To exclude indirect eff...