ea0032p721 | Nuclear receptors and signal transduction | ECE2013
Pesiri Valeria
, Acconcia Filippo
Protein ubiquitination modulates many physiological processes (e.g. cell proliferation). The ubiquitin-based signalling consists in both proteolytic and non-proteolytic functions: the first ones require modification of the target protein with polyubiquitination, a modification that induces the activation of the 26S-proteasome, whereas the second ones can be based on protein monoubiquitination. The recognition of ubiquitination diversity is dependent on specific Ub receptors th...