Searchable abstracts of presentations at key conferences in endocrinology

ea0014p636 | (1) | ECE2007

The multi-PDZ domain protein MUPP1: a scaffolding protein controlling the acrosome reaction in mammalian spermatozoa

Ackermann Frauke , Meyer Dorke , Heydecke Diana , Wilhelm Beate , Gudermann Thomas , Boekhoff Ingrid

Upon adhesion to the zona pellucida, mammalian sperm undergo regulated exocytosis of the acrosome. Despite the difference in size, some parallels can be drawn concerning the signal transduction processes controlling the sperm acrosome reaction and synaptic vesicle exocytosis. Since components of signal transduction pathways are often organized in multiprotein signalling complexes, attempts were made to identify scaffolding proteins expressed in the acrosomal region of mammalia...