Searchable abstracts of presentations at key conferences in endocrinology

ea0028p193 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2012

Annexin A1, an anti-inflammatory regulator, is expressed in human adipocytes

Kosicka-Knox Anna , Cunliffe Adam , Mackenzie Richard , Zariwala Mohammed , Renshaw Derek

Annexin A1 (AnxA1), an endogenous glucocorticoid regulated protein, is a pivotal homeostatic regulator of the magnitude of the inflammatory response. We have previously demonstrated that plasma AnxA1 protein is significantly inversely correlated with waist to hip ratio (P=0.017). Given that low-level systemic inflammation is seen in metabolic syndrome-associated chronic pathologies, here, we investigate if AnxA1 is also involved in the regulation of adipose tissue infla...

ea0025p133 | Diabetes, metabolism and cardiovascular | SFEBES2011

Plasma Annexin A1 (AnxA1) is inversely correlated with waist to hip ratio in healthy males

Kosicka-Knox Anna , Cunliffe Adam , Mackenzie Richard , Flower Rod , Renshaw Derek

The escalating public health problem represented by obesity has spurred multidisciplinary research into adipose tissue and importantly, the molecular biology of the adipocyte. Recent studies suggest that obesity related metabolic disorders are characterised by chronic mild inflammation as a result of adipocytokine production from fat tissue leading to dysregulation in the pro/anti-inflammatory systemic balance. Adipokines and pro-inflammatory markers are implicated in insulin ...