Searchable abstracts of presentations at key conferences in endocrinology

ea0056oc6.2 | Genetic and environmental determinants of obesity and insulin resistance | ECE2018

Deep transcranial magnetic stimulation acutely modulates neuro-endocrine pathways underlying obesity

Ferrulli Anna , Adamo Michela , Massarini Stefano , Luzi Livio

Deep Transcranical Magnetic Stimulation (dTMS) is a non-invasive modulation technique of cortical excitability that has shown to affect the mesolimbic and mesostriatal dopaminergic pathways. Consistent with these assets, dTMS is widely used as a therapeutic tool in neuro-psychiatric disorders associated with abnormal cortical excitability and dopaminergic activity, as addiction. Hence, considering the dysfuncional role of PFC and dopaminergic reward system in controlling appet...

ea0081oc12.3 | Oral Communications 12: Reproductive and Developmental Endocrinology | ECE2022

Defective Notch1/Jag1 signaling impacts GnRH development and contributes to hypogonadotropic hypogonadism

Ludovica Cotellessa , Federica Marelli , Duminuco Paolo , Lucia Bartoloni , Michela Adamo , Pitteloud Nelly , Persani Luca , Bonomi Marco , Giacobini Paolo , Valeria Vezzoli

The precise development of the Gonadotropin Releasing Hormone (GnRH) neurons is essential for the proper function of the hypothalamic-pituitary-gonadal axis, as GnRH is the master regulator of reproductive functions in vertebrates. Mutations in genes involved in the development of GnRH neurons are associated with Congenital Hypogonadotropic Hypogonadism (CHH), a heterogeneous genetic disorder characterized by hypogonadism, lack of puberty onset, and infertility, which is named...

ea0081rc12.4 | Rapid Communications 12: Reproductive and Developmental Endocrinology | ECE2022

Unraveling the link between metabolism and reproduction in obese men

Papadakis Georgios , Lucie Favre , Zouaghi Yassine , Vionnet Nathalie , Niederlander Nicolas , Adamo Michela , Acierno James , Santoni Federico , Berdous Dassine , Spoerl Alexia , Paccou Emmanuelle , Aleman Yasser , Salamin Olivier , Hagmann Patrick , Messina Andrea , Pitteloud Nelly

Introduction: Obesity is a worldwide pandemic, and in men can often be associated with hypogonadotropic hypogonadism (HH), a finding consistent with a clear link between sex steroids and reproduction. In this study, we aimed to characterize the phenotypic spectrum of male obesity, focusing on the metabolic and reproductive effect of weight loss after bariatric surgery, as well as to explore the role of central inflammation.Methods: We conducted an observ...