Searchable abstracts of presentations at key conferences in endocrinology

ea0021oc1.8 | Diabetes and metabolism | SFEBES2009

Cortisol metabolism and hepatic expression of 11β-hydroxysteroid dehydrogenase type 1 in patients with non-alcoholic fatty liver disease

Ahmed Adeeba , Brady Theresa , Bailey Claire , Guest Phillip , Wagenmakers Anton , Newsome Phillip , Hubscher Stephan , Elias Elwyn , Adams David , Tomlinson Jeremy , Stewart Paul

Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome. The role of glucocorticoids (GC) in its pathogenesis, is highlighted in patients with GC excess, CushingÂ’s syndrome, who develop central adiposity, insulin resistance and in 20% of cases, NAFLD. Although circulating cortisol levels are normal in patients with NAFLD, hepatic cortisol availability is controlled by enzymes that regenerate cortisol from inactive cortisone (11&#94...