Searchable abstracts of presentations at key conferences in endocrinology

ea0086p81 | Metabolism, Obesity and Diabetes | SFEBES2022

Altered Androgen Metabolism in Rheumatoid Arthritis Influences Synoviocyte Function

Crastin Ana , Martin Claire S. , Adams Holly R. , Raza Karim , Filler Andrew , Hardy Rowan S.

Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterised by progressive joint destruction and inflammatory activation and hyperproliferation of synoviocytes. We have previously reported a marked shift towards reduced local androgen metabolism in active RA, driven by changing expression of SRD5A1 and AKR1C3 within macrophages. In this study we examined the role of altered androgen metabolism and availability in the inflammatory function of both macr...