Endocrine Abstracts

Introduction: β cells are a major target of therapeutic strategies to treat diabetes and are extensively studied in terms of their differentiation, function, and maintenance. β cell mass dynamically changes in response to altered metabolic demands in an organism. Many therapies are suggested including transplantation of pancreas or islet cells for type 1 diabetes patients, however these procedures are associated with significant risks and costs. Hence, search for new...

Introduction: Incidence of diabetes mellitus worldwide is on the rise, and better methods of prevention and treatment are needed. We evaluated the possible antidiabetic effect of embryonic antitumor modulator (EATM) created by Mkrtchyan, which reportedly exhibit anticancer, neuroprotective and immunomodulatory properties.Materials and methods: Rats with streptozotocin (STZ)-induced diabetes (55 mg/kg once i.p.) were injected EATM (1 mg/200 g rat body mas...

Introduction: Embryonal antitumour modulator of Mkrtchyan (EATM) reveals a hypoglycemic effect in streptozotocin-induced diabetes in rats. The aim of the work was to determine the influence of EATM on the process of releasing of Nox of erythrocyte membranes (EM) and serum of patients with diabetes type 1 and 2.Materials and methods: The study included 12 patients with type 1 diabetes, 12 patients with type 2 diabetes and 12 healthy volunteers. Isolation ...

Introduction: Congenital hyperinsulinism is the most common cause for recurrent hypoglycaemia in neonates and infants. Uncontrolled hypoglycaemia leads to seizures and long-term cerebral damage. Herein, we report a case of congenital hyperinsulinism (persistent hyperinsulinaemic hypoglycaemia of infancy, nesidioblastosis) and review of the relevant literature regarding on the aetiology, pathogenesis, clinical and pathological features, diagnosis and treatment of this disorder....

Introduction: Radiation treatment is used for patients with secreting and non-secreting pituitary adenomas, residual pituitary adenomas, or recurrent pituitary adenomas to achieve long term disease control. The hypothalamic–pituitary unit is a particularly radiosensitive region in the central nervous system and pituitary hormone deficiencies are the commonest late complication of radiotherapy, which usually occur after several years. The development of hormone deficiencie...

Introduction: Methimazole is an antithyroid medication which is now considered the first line agent for medical therapy of Graves’ disease. Rare complications of methimazole (<1%) include agranulocytosis, aplastic anemia, nephritis and hepatitis. We would like to report the rare case of the patient with Methimazole-induced hepatitis.Case Presentation: A 46-year-old woman, who complained of fatigue, loss of appetite, nausea, vomiting, jaundice, d...

Introduction: Cushing’s disease (CD) is the most common albeit rare in paediatric and adolescent population form of ACTH-dependent Cushing’s syndrome, with potentially serious morbidity. Thus, it presents diagnostic and therapeutic challenges for the clinician. Early diagnosis and treatment of Cushing’s disease is vital for long-term outcome. Paediatric pituitary-dependent Cushing’s disease, caused by an ACTH-secreting corticotroph adenoma, accounts for 75&...

Background: Virginal breast hypertrophy is a rare benign disease. It is a condition of abnormal enlargement of the breast tissue and is characterized by rapid and excessive growth of one or two breasts during peripubertal period. This condition causes significal psychological and physical discomfort to affected adolescents, such as feeling embarrassed, inability to find appropriate clothes, suffering from back and shoulders pain, perhaps the appearance of kyphosis under the we...

Introduction: Wolfram Syndrome is a rare autosomal recessive progressive neurodegenerative disorder with estimated prevalence of 1 in 500,000 r, also known as DIDMOAD syndrome for its four most common features (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy and Deafness). Patients present with nonautoimmune and non-HLA linked diabetes mellitus associated with optic atrophy in the first decade, diabetes insipidus and sensorineural deafness in the second decade, renal trac...

Background and aims: A growing number of studies show the impact of vitamin D deficiency on chronic diseases, such as obesity, type 2 diabetes, cardiovascular disorders etc. Recently the lower limit of vitamin D sufficiency, appeared to be safe and sufficient for skeletal health in the healthy general population, was documented as 20 ng/ml (50 nmol/l). The aim of current work is to evaluate whether the 25-OH vitamin D status is associated with the glucose control in type ...