ea0013p3 | Bone | SFEBES2007
Joseph Franklin
, Ahmad Aftab M
, Joshi Ashwin
, Wakil Amar
, Durham Brian H
, Whittingham Pauline
, Fraser William D
, Vora Jiten P
Introduction: Adult growth hormone deficiency (AGHD) is associated with target organ insensitivity to parathyroid hormone (PTH) and abnormal PTH circadian rhythm. In aging women with established osteoporosis, GH and insulin like growth factor -1 (IGF-1) concentrations are low and administration of GH has been shown to increase bone turnover and bone mineral density (BMD), but the mechanisms remain unclear. Consequently we investigated the effects of declining GH and IGF-1 conc...