Endocrine Abstracts

Introduction: - Primary hyperparathyroidism is a relatively common disorder affecting 1 in 500 women and 1 in 2000 men aged over 40 years. - Diagnosis of primary hyperparathyroidism is confirmed biochemically with synchronous elevation of serum calcium and inappropriate elevation of parathyroid hormone. - Parathyroid adenomas are the most common aetiology. Around 80% are a single, benign adenoma, which in most cases is sporadic. Multiple adenomas and hypertrophy of all 4 gland...

44 years old gentleman referred to endocrinology clinic complaining of reduced libido. Initial blood test showed borderline low testosterone levels measuring 8.4 nmol/l (10–37) on 2016. SHBG 28. He has a past medical history of type 2 diabetes diagnosed March 2015, fibromyalgia, bilateral carpal tunnel syndrome, spinal osteoarthritis and asthma. medication includes Amitriptyline 30 OD, Buprenorphine 15 μg patches weekly and inhalers together with metformin and sitagl...

Multiple endocrine neoplasia type 1 (MEN1) and MEN) are distinct clinical and genetic entities.This talk will cover the key clinical features and surveillance strategies for each of these conditions....

Contemporary therapies to rationalize the hyperglycaemia in type 2 diabetes mellitus (T2DM) generally involve insulin-dependent mechanisms and lose their effectiveness as pancreatic b-cell function decreases to a greater extent. Kidney emerges out as a novel and potential target to trim down the T2DM. The filtered glucose is reabsorbed principally through the sodium glucose co-transporter-2 (SGLT2), a low affinity transport system, which are present at the luminal surface cell...

Aim: To review the local clinical practice of use of third agent in the treatment of type 2 diabetes and comparison of clinical efficacy of available third agents and patient motivation with these agents. Method: We used the computerized records of type 2 diabetic patients who were started on third pharmacological agent (tablets, insulin, exenatide or liraglutide) or GLP-1 agonists which may not be the third agent and followed them up for 6 months. Medical notes were used if a...

Contemporary therapies to trim down the hyperglycaemia in type 2 diabetes mellitus (T2DM) generally involve insulin-dependent mechanisms and lose their effectiveness as pancreatic b-cell function decreases to a greater extent. Kidney emerges out as a novel and potential target to trim down the T2DM. The filtered glucose is reabsorbed principally through the sodium glucose co-transporter-2 (SGLT2), a low affinity transport system, which are present at the luminal surface cells ...

Infants rarely present with truly ambiguous genitalia and such children should be evaluated by experts who work within a multidisciplinary team that is dedicated for evaluation and management of children and adults with suspected and confirmed disorders of sex development. The paediatric endocrinologist who is a vital, and often, the central member of this clinical team needs to lead the clinical evaluation of the infant systematically but also needs to be sensitive to the nee...

A 34-year-old T1DM nurse was admitted with a history of recurrent episodes of DKA. In the current admission at our hospital, on detailed history she reported of getting DKA almost every month when her menses would start. She would be following the sick day rules of DKA but it wouldn’t help prevent her going into DKA. No other precipitating factors were found. She was diagnosed as a case of Catamenial DKA and was started on OCP’s to see how what effect it would have o...

The Case: We are presenting a 51-year-old Caucasian lady with known type 1 diabetes who was diagnosed with Autoimmune Addison’s Disease (AAD) during investigation of persistent hyponatremia. She was admitted with DKA back in November 2022 that was believed to be due to gastroenteritis. Usually, her diabetes control has been reasonable over the years with no severe chronic complications or diabetes-related hospital admissions. In the hospital, she suffered from ongoing hyp...

We are a presenting a 57 year old male victim of recurrent metastatic melanoma who was treated surgically in 2015 by wide local excision together with right axillary dissection for axillary nodal spread. He re-presented to dermatology clinic in December 2018 with skin lesion that was histologically proven to be a BRAF-mutant malignant melanoma. CT scans at that time showed spread to mediastinal and hilar nodes. Oncology team decided to commence Iplimumab/Nivolumab combination ...