Searchable abstracts of presentations at key conferences in endocrinology

ea0024p46 | (1) | BSPED2010

Trends in clinical activity of a paediatric bone densitometry service

Khanna S , Logan J , Ahmed S F

Background: Bone densitometry by DXA is now considered routine part of clinical management of children at risk of osteoporosis. Data on activity of a paediatric DXA service would be helpful for service planning but are currently lacking.Aim: A survey of referrals to the service and size-adjusted total body (TB) and lumbar spine (LS) bone mineral content for bone-area standard deviation scores (BMC for BA SDS) were obtained from the local database.<p ...

ea0039ep98 | Other | BSPED2015

Cardiovascular assessment in Turner syndrome: current practice in the UK

Mason A , Smyth A , Ahmed S F , Wong S C

Background: In 2007, the Turner syndrome (TS) consensus study group developed an international guideline for clinical care of girls and women with TS. Given emerging concerns of long term cardiovascular complications, the consensus recommends that cardiac MRI should be performed when girls are old enough to tolerate the procedure or at the time of transition and to be repeated at least every 5–10 years.Method: We conducted a survey ...

ea0024p13 | (1) | BSPED2010

The European DSD register – the start of an international DSD network

Rodie M , Jiang J , Sinnott R , Ahmed S F

To improve the clinical management of children with disorders of sex development (DSD), there is a need for multi-centre collaborative research as well as clinical interaction. The European DSD Register that became operational in 2008 is a cornerstone of the EuroDSD programme and allows clinicians and researchers to interact in a secure, internet-based, virtual research environment (VRE).Currently, 23 centres in 16 countries from four continents have exp...

ea0039ep18 | Bone | BSPED2015

Trends of use of bisphosphonates in children with secondary osteoporosis

Henderson S , Alhashem G , Shaikh G , Mason A , Ahmed S F , Wong S C

Aim: To review trends in bisphosphonate use in children with secondary osteoporosis attending a Tertiary Paediatric Endocrine Unit (2004–July 2015).Methods: Data were gathered from a combination of a clinical and pharmacy database. Results reported as median (range).Results: A total of 42 children (19M) commenced on bisphosphonates treatment over the 11-year period, median age 11.8 years (3.3–18.4). 19 were on pamidronate...

ea0036oc4.8 | Oral Communications 4 | BSPED2014

Recombinant human GH in paediatric inflammatory bowel disease: short term effects on bone biomarkers and long term effects on bone and lean mass

Altowati M A , Shepherd S , McGrogan P , Russell R K , Wong S C , Ahmed S F

Background: Recombinant human GH (rhGH) may improve bone mass in paediatric inflammatory bowel disease (IBD).Objective: To investigate rhGH on bone and body composition in paediatric IBD.Method: Bone biomarkers were evaluated in 12 children, 11CD (10M), median age 14.4 year (8.9, 16.2) who received rhGH (0.067 mg/kg per day) as part of a 6 months RCT. Eight received rhGH for 24 months and had DXA evaluation. Results were reported a...

ea0036P57 | (1) | BSPED2014

Effect of vitamin D treatment on glucose and insulin metabolism, and bone turnover in children with symptomatic vitamin D deficiency

El-Fakhri Nagla , McMillan Martin , McNeilly Jane , Ahmed S F , McDevitt Helen

Background: There are limited data in paediatric population on the association between vitamin D deficiency/treatment and glucose/insulin metabolism.Objective and hypotheses: This study aimed to investigate the effect of vitamin D therapy on glucose homeostasis, insulin resistance and bone turnover, in children with vitamin D deficiency.Method: 22 children aged 3 months to 10 years (nine males) who were diagnosed with vitamin D def...

ea0036P69 | (1) | BSPED2014

Bone mass and body composition in adolescents with childhood onset GH deficiency

Ahmid M , Shepherd S , Perry C G , Mason A , Ahmed S F , Shaikh M G

Background: Childhood-onset GH deficiency (CO-GHD) is perceived to be a cause of low bone density and osteoporosis in adulthood. Data on bone mass and body composition of GH-treated adolescents with CO-GHD at final height are inconsistent.Aims: To compare size/height corrected parameters of bone mass and body composition in adolescents with CO-GHD at final height.Method: Review of CO-GHD treated patients at final height between 200...

ea0033p1 | (1) | BSPED2013

Plasma cortisol levels and adrenal weight in cases of death in childhood

Morrison R. , Khan J , Galloway P , McNeilly J , Penman D , Ahmed S F

Introduction: The incidence of adrenal insufficiency in cases of unexplained death in young children is unclear. It is also unclear whether there is a relationship between adrenal size and plasma cortisol concentration.Methods: All post-mortem (PM) reports of sudden deaths in children in the West of Scotland between 2010 and 2012 were retrospectively analysed. Combined adrenal weight (g) was recorded and expressed as the percentage of total body weight (...

ea0030p54 | (1) | BSPED2012

Management of childhood-onset GH deficiency in young adulthood

Ahmid Mahjouba , Perry C G , Donaldson M , Ahmed S F , Shaikh M G

Background: GH therapy in adolescents with childhood onset GH deficiency (CO-GHD) is often necessary to prevent adult GHD syndrome and requires a re-evaluation of the GH axis on attainment of final height. Not all individuals with CO-GHD remain GH deficient and re-evaluation is required to confirm or refute adult GHD.Aim: Review the care received by young adults diagnosed with CO-GHD.Design: Retrospective review of young adults wit...

ea0024p23 | (1) | BSPED2010

The impact of inflammatory bowel disease on pubertal growth is most marked in boys with Crohn’s disease

Mason A , Malik S , Russell R K , Bishop J , McGrogan P , Ahmed S F

Background: Puberty is understood to be commonly effected in adolescents with Crohn’s Disease (CD) and ulcerative colitis (UC). However, the extent of this effect and related problems with growth, have rarely been quantified.Objective: To determine the impact of CD and UC on pubertal growth.Methods: Retrospective study of 148 children with IBD (casenotes available, 135) who fulfilled the criteria for describing growth spurt pa...